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Nutmeg

What other names is Nutmeg known by?

Jaatipatree, Jaiphal, Jatiphal, Jatiphala, Jatiphalam, Muscade, Muscade et Macis, Muscadier, Muskatbaum, Muskatnuss, Myristica, Myristica fragrans, Myristica officinalis, Myristicae Semen, Noix de Muscade, Noix de Muscade et Macis, Nuez Moscada, Nuez Moscada y Macis,Nutmeg, Nux Moschata, Ron Dau Kou.

What is Nutmeg?

Nutmeg and mace are plant products. Nutmeg is the shelled, dried seed of the plant Myristica fragrans, and mace is the dried net-like covering of the shell of the seed. Myristica fragrans is native to the Banda Islands of Indonesia. The tree is now grown in several other tropical regions, such as Malaysia and the Caribbean. Grenada is also one of the world's greatest nutmeg exporters.

Nutmeg is taken by mouth for diarrhea, nausea, stomach spasms and pain, and intestinal gas. It is also taken by mouth for treating cancer, kidney disease, and trouble sleeping (insomnia); increasing menstrual flow; causing a miscarriage; as a hallucinogen; and as a general tonic.

Nutmeg is applied to the skin to kill pain, especially pain caused by mouth sores, and toothache.

In foods, nutmeg is used as a spice and flavoring.

In manufacturing, nutmeg oil is used as a fragrance in soaps and cosmetics. Nutmeg oil is distilled from worm-eaten nutmeg seeds. The worms remove much of the starch and fat, leaving the portions of the seed that are rich in oil.

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of nutmeg and mace for these uses.

How does Nutmeg work?

Nutmeg contains chemicals that might affect the central nervous system. Nutmeg might also kill bacteria and fungi.

Are there safety concerns?

Nutmeg is POSSIBLY SAFE when taken by mouth and used appropriately. Nutmeg is a commonly used spice in foods.

Nutmeg is POSSIBLY UNSAFE when taken by mouth in doses larger than amounts found in foods and for long periods of time. Long-term use of nutmeg in doses of 120 mg or more daily has been linked to hallucinations and other mental side effects. People who have taken larger doses of nutmeg have experienced nausea, dry mouth, dizziness, irregular heartbeat, agitation and hallucinations. Other serious side effects have included death.

There is not enough reliable information available to know if nutmeg is safe when applied to the skin or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Nutmeg is POSSIBLY UNSAFE when taken by mouth in doses larger than amounts found in foods. In pregnant women, it might cause miscarriages or birth defects.

There is not enough reliable information about the safety of taking nutmeg if you are breast feeding. Stay on the safe side and avoid use.

Infertility: Early research suggests that taking high doses might reduce fertility in men. Avoid nutmeg if you are trying to have a baby.

Are there any interactions with medications?


Drying medications (Anticholinergic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Nutmeg might increase levels of certain chemicals in the body that work in the brain, heart, and elsewhere. Some drying medications called "anticholinergic drugs" can also these same chemicals, but in a different way. These drying medications might decrease the effects of nutmeg, and nutmeg might decrease the effects of drying medications.
Some of these drying medications include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).


Medications changed by the liver (Cytochrome P450 1A1 [CYP1A1] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Nutmeg might increase how quickly the liver breaks down some medications. Taking nutmeg along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking nutmeg talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include chlorzoxazone, theophylline, bufuralol, and others.


Medications changed by the liver (Cytochrome P450 1A2 [CYP1A2] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver.

Nutmeg might increase how quickly the liver breaks down some medications. Taking nutmeg along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking nutmeg talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.


Medications changed by the liver (Cytochrome P450 2B1 [CYP2B1] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver.

Nutmeg might increase how quickly the liver breaks down some medications. Taking nutmeg along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking nutmeg talk to your healthcare provider if you take any medications that are changed by the liver.


Medications changed by the liver (Cytochrome P450 2B2 [CYP2B2] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver.

Taking nutmeg along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking nutmeg talk to your healthcare provider if you take any medications that are changed by the liver.


Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Nutmeg might increase certain chemicals in the brain, heart, and elsewhere in the body. Some medications used for Alzheimer's disease also affect these chemicals. Taking nutmeg along with medications for Alzheimer's disease might increase effects and side effects of medications used for Alzheimer's disease. Some medications used for Alzheimer's disease include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).


Phenobarbital (Luminal)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

The body breaks down phenobarbital (Luminal) to get rid of it. Nutmeg might increase how quickly the body breaks down phenobarbital (Luminal). Taking nutmeg along with phenobarbital (Luminal) might decrease the effectiveness of phenobarbital (Luminal).


Sedative medications (CNS depressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Nutmeg might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. In theory, taking nutmeg along with sedative medications might cause too much sleepiness.
Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.


Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Nutmeg might increase certain chemicals in the brain, heart, and elsewhere in the body. Some medications used for glaucoma, Alzheimer's disease, and other conditions also affect these chemicals. Taking nutmeg with these medications might increase the chance of side effects.
Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Dosing considerations for Nutmeg.

The appropriate dose of nutmeg depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for nutmeg (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019
References

Al Bataina, B. A., Maslat, A. O., and Al Kofahil, M. M. Element analysis and biological studies on ten oriental spices using XRF and Ames test. J Trace Elem.Med Biol. 2003;17(2):85-90. View abstract.

Beljaars, P. R., Schumans, J. C., and Koken, P. J. Quantitative fluorodensitometric determination and survey of aflatoxins in nutmeg. J Assoc.Off Anal.Chem. 1975;58(2):263-271. View abstract.

Calucci, L., Pinzino, C., Zandomeneghi, M., Capocchi, A., Ghiringhelli, S., Saviozzi, F., Tozzi, S., and Galleschi, L. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices. J Agric.Food Chem 2-12-2003;51(4):927-934. View abstract.

Chung, J. Y., Choo, J. H., Lee, M. H., and Hwang, J. K. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine 2006;13(4):261-266. View abstract.

Culikova, V. Assortment of the plants in the Medieval diet in Czech countries (based on archaeobotanical finds). Acta Univ Carol.Med (Praha) 2000;41(1-4):105-118. View abstract.

Firouzi, R., Shekarforoush, S. S., Nazer, A. H., Borumand, Z., and Jooyandeh, A. R. Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken. J Food Prot. 2007;70(11):2626-2630. View abstract.

Hasheminejad, G. and Caldwell, J. Genotoxicity of the alkenylbenzenes alpha- and beta-asarone, myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes. Food Chem.Toxicol. 1994;32(3):223-231. View abstract.

Jensen-Jarolim, E., Gajdzik, L., Haberl, I., Kraft, D., Scheiner, O., and Graf, J. Hot spices influence permeability of human intestinal epithelial monolayers. J Nutr. 1998;128(3):577-581. View abstract.

Kamble VA and Patil SD. Spice derived essential oils: effective antifungal and possible therapeutic agents. Journal of Herbs, Spices & Medicinal Plants (J HERBS SPICES MEDICINAL PLANT) 2008;14(3-4):129-143.

Kresanek, J., Plackova, S., Caganova, B., and Klobusicka, Z. Drug abuse in Slovak Republic. Przegl.Lek. 2005;62(6):357-360. View abstract.

Lis-Balchin, M. and Hart, S. A preliminary study of the effect of essential oils on skeletal and smooth muscle in vitro. J Ethnopharmacol 1997;58(3):183-187. View abstract.

Mahady, G. B., Pendland, S. L., Stoia, A., Hamill, F. A., Fabricant, D., Dietz, B. M., and Chadwick, L. R. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother.Res 2005;19(11):988-991. View abstract.

Maralhas, A., Monteiro, A., Martins, C., Kranendonk, M., Laires, A., Rueff, J., and Rodrigues, A. S. Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol. Mutagenesis 2006;21(3):199-204. View abstract.

Martins, M. L., Martins, H. M., and Bernardo, F. Aflatoxins in spices marketed in Portugal. Food Addit.Contam 2001;18(4):315-319. View abstract.

Masatcioglu, T. M. and Avsar, Y. K. Effects of flavorings, storage conditions, and storage time on survival of Staphylococcus aureus in Surk cheese. J Food Prot. 2005;68(7):1487-1491. View abstract.

Miller, E. C., Swanson, A. B., Phillips, D. H., Fletcher, T. L., Liem, A., and Miller, J. A. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res 1983;43(3):1124-1134. View abstract.

Murcia, M. A., Egea, I., Romojaro, F., Parras, P., Jimenez, A. M., and Martinez-Tome, M. Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure. J Agric.Food Chem. 4-7-2004;52(7):1872-1881. View abstract.

O'Mahony, R., Al Khtheeri, H., Weerasekera, D., Fernando, N., Vaira, D., Holton, J., and Basset, C. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol. 12-21-2005;11(47):7499-7507. View abstract.

Park, I. K., Kim, J. N., Lee, Y. S., Lee, S. G., Ahn, Y. J., and Shin, S. C. Toxicity of plant essential oils and their components against Lycoriella ingenua (Diptera: Sciaridae). J Econ.Entomol. 2008;101(1):139-144. View abstract.

Randerath, K., Haglund, R. E., Phillips, D. H., and Reddy, M. V. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice. Carcinogenesis 1984;5(12):1613-1622. View abstract.

Smith-Palmer, A., Stewart, J., and Fyfe, L. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Lett Appl Microbiol. 1998;26(2):118-122. View abstract.

Smith-Palmer, A., Stewartt, J., and Fyfe, L. Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils. J Med Microbiol. 2002;51(7):567-574. View abstract.

Valero, M. and Salmeron, M. C. Antibacterial activity of 11 essential oils against Bacillus cereus in tyndallized carrot broth. Int.J Food Microbiol. 8-15-2003;85(1-2):73-81. View abstract.

Veal, L. The potential effectiveness of essential oils as a treatment for headlice, Pediculus humanus capitis. Complement Ther Nurs.Midwifery 1996;2(4):97-101. View abstract.

Verluyten, J., Leroy, F., and De Vuyst, L. Effects of different spices used in production of fermented sausages on growth of and curvacin A production by Lactobacillus curvatus LTH 1174. Appl.Environ Microbiol. 2004;70(8):4807-4813. View abstract.

Zhou, G. D., Moorthy, B., Bi, J., Donnelly, K. C., and Randerath, K. DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human (HepG2) cells. Environ.Mol.Mutagen. 2007;48(9):715-721. View abstract.

Shah AM, Calello DP, Quintero-Solivan J, Osterhoudt KC. The not-so-nice spice: a teenage girl with palpitations and dry mouth. Pediatr Emerg Care 2011;27:1205-7. View abstract.

- Sharma A, Mathur R, Dixit VP. Prevention of hypercholesterolemia and atherosclerosis in rabbits after supplementation of Myristica fragrans seed extract. Indian J Physiol Pharmacol. 1995;39(4):407-10. View abstract.

Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. View abstract.

Ahmad A, Thompson HS. Nutmeg mydriasis. JAMA. 1975;234(3):274. View abstract.

Akiyama, H., Goda, Y., Tanaka, T., and Toyoda, M. Determination of aflatoxins B1, B2, G1 and G2 in spices using a multifunctional column clean-up. J Chromatogr.A 10-12-2001;932(1-2):153-157. View abstract.

Al-Jumaily EF, Al-Amiry MHA. Extraction and Purification of Terpenes from Nutmeg (myristica fragrans) J Al-Nahrain Univ 2012;15(3)151-160.

Ananthakumar A, Variyar PS, Sharma A. Estimation of aroma glycosides of nutmeg and their changes during radiation processing. J Chromatogr A. 2006;1108(2):252-7. View abstract.

Archer AW. Determination of safrole and myristicin in nutmeg and mace by high-performance liquid chromatography. J Chromatogr. 1988;438(1):117-21. View abstract.

Awe, M. J. and Schranz, J. L. High pressure liquid chromatographic determination of aflatoxins in spices. J Assoc.Off Anal.Chem. 1981;64(6):1377-1382. View abstract.

Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. View abstract.

Barrowman JA, Bennett A, Hillenbrand P, Rolles K, Pollock DJ, Wright JT. Diarrhoeae in thyroid medullary carcinoma: role of prostaglandins and therapeutic effect of nutmeg. Br Med J. 1975;3(5974):11-2. View abstract.

Beattie RT. Nutmeg as a psychoactive agent. Br J Addict Alcohol Other Drugs. 1968;63(1):105-9. View abstract.

Beyer J, Ehlers D, Maurer HH. Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther Drug Monit. 2006;28(4):568-75. View abstract.

Brenner N, Frank OS, Knight E. Chronic nutmeg psychosis. J R Soc Med 1993;86:179-80. View abstract.

Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 2000;48:849-52.. View abstract.

Capasso R, Pinto L, Vuotto ML, Di Carlo G. Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. Fitoterapia. 2000;71 Suppl 1:S131-7. View abstract.

Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. View abstract.

Chirathaworn C, Kongcharoensuntorn W, Dechdoungchan T, Lowanitchapat A, Sa-nguanmoo P, Poovorawan Y. Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J Med Assoc Thai. 2007;90(11):2422-8. View abstract.

Cho JY, Choi GJ, Son SW, et al. Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi. Pest Manag Sci. 2007;63(9):935-40. View abstract.

Cho Y, Kim KH, Shim JS, Hwang JK. Inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanin biosynthesis. Biol Pharm Bull. 2008;31(5):986-9. View abstract.

Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22:223-5. View abstract.

Dhingra D, Parle M, Kulkarni SK. Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice. J Med Food. 2006;9(2):281-3. View abstract.

Dhingra D, Sharma A. Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. J Med Food. 2006;9(1):84-9. View abstract.

Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.

Duan L, Tao HW, Hao XJ, Gu QQ, Zhu WM. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans. Planta Med. 2009;75(11):1241-5. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182

Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

Forrest JE, Heacock RA, Forrest TP. Diarylpropanoids from nutmeg and mace (Myristica fragrans Houtt.). J Chem Soc Perkin 1. 1974;2:205-9. View abstract.

Forrest JE, Heacock RA. A chromatographic comparison of the constituents of nutmeg and mace (Myristica fragrans Houtt.) with those of marihuana and hashish (Cannabis sativa L.). J Chromatogr. 1974;89(1):113-7. View abstract.

Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. View abstract.

Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80. View abstract.

Futrell JM, Rietschel RL. Spice allergy evaluated by results of patch tests. Cutis. 1993;52(5):288-90. View abstract.

Gonçalves JL, Lopes RC, Oliveira DB, et al. In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea. J Ethnopharmacol. 2005;99(3):403-7. View abstract.

Goryacheva, I. Y., De Saeger, S., Lobeau, M., Eremin, S. A., Barna-Vetro, I., and Van Peteghem, C. Approach for ochratoxin A fast screening in spices using clean-up tandem immunoassay columns with confirmation by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Anal.Chim.Acta 9-1-2006;577(1):38-45. View abstract.

Goryacheva, I. Y., De Saeger, S., Nesterenko, I. S., Eremin, S. A., and Van Peteghem, C. Rapid all-in-one three-step immunoassay for non-instrumental detection of ochratoxin A in high-coloured herbs and spices. Talanta 5-15-2007;72(3):1230-1234. View abstract.

Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. View abstract.

Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. View abstract.

Hashim S, Aboobaker VS, Madhubala R, Bhattacharya RK, Rao AR. Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro. Nutr Cancer. 1994;21(2):169-75. View abstract.

Ho SC, Tsai TH, Tsai PJ, Lin CC. Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage. Food Chem Toxicol. 2008;46(3):920-8. View abstract.

Inder WJ, Swanney MP, Donald RA, et al. The effect of glycerol and desmopressin on exercise performance and hydration in triathletes. Med Sci Sports Exerc 1998;30:1263-9. View abstract.

Jaiswal P, Singh DK. Molluscicidal activity of nutmeg and mace (Myristica fragrans Houtt.) against the vector snail Lymnaea acuminata. J Herbs Spices Medicinal Plant 2009;15(2):177-186.

Janssens J, Laekeman GM, Pieters LA, et al. Nutmeg oil: identification and quantitation of its most active constituents as inhibitors of platelet aggregation. J Ethnopharmacol. 1990;29(2):179-88. View abstract.

Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. View abstract.

Jung WC, Jang YS, Hieu TT, Lee CK, Ahn YJ. Toxicity of Myristica fagrans seed compounds against Blattella germanica (Dictyoptera: Blattellidae). J Med Entomol. 2007;44(3):524-9. View abstract.

Kalbhen DA. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans). Angew Chem Int Ed Engl. 1971;10(6):370-4. View abstract.

Kelly BD, Gavin BE, Clarke M, et al. Nutmeg and psychosis. Schizophr Res 2003;60:95-6. View abstract.

Kim YB, Park IY, Shin KH. The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans. Arch Pharm Res. 1991;14(1):1-6. View abstract.

Krol CG, Janssen MJ. Unusual use of nutmeg. Ned Tijdschr Geneeskd 2010;154:A2214. View abstract.

Kuo YH, Kao ST, Lin YT. Extractive components from the nutmeg of Myristica simarum A.DC.: the structure of lignan-ketone: otobanone. Experientia. 1976;32(7):828-9. View abstract.

Kuo YH. Studies on several naturally occurring lignans. Gaoxiong Yi Xue Ke Xue Za Zhi. 1989 Nov;5(11):621-4. View abstract.

Kwon HS, Kim MJ, Jeong HJ, et al. Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds. Bioorg Med Chem Lett. 2008;18(1):194-8. View abstract.

Lee BK, Kim JH, Jung JW, et al. Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. Toxicol Lett. 2005;157(1):49-56. View abstract.

Lee HS, Jeong TC, Kim JH. In vitro and in vivo metabolism of myristicin in the rat. J Chromatogr B Biomed Sci Appl. 1998;705(2):367-72. View abstract.

Li F, Yang XW. Biotransformation of myrislignan by rat liver microsomes in vitro. Phytochemistry. 2008;69(3):765-71. View abstract.

Li F, Yang XW. Determination of dehydrodiisoeugenol in rat tissues using HPLC method. Biomed Chromatogr. 2008;22(11):1206-12. View abstract.

Li W, Yao L, Mi S, Wang N. [The effect of borneol on level of HA and 5-HT in rat's hypothalamus]. Zhong Yao Cai. 2004;27(12):937-9. View abstract.

Ma J, Hwang YK, Cho WH, et al. Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells. Biol Pharm Bull. 2009;32(6):1085-90. View abstract.

Maeda A, Tanimoto S, Abe T, Kazama S, Tanizawa H, Nomura M. [Chemical constituents of Myristica fragrans Houttuyn seed and their physiological activities]. Yakugaku Zasshi. 2008;128(1):129-33. View abstract.

Maloney C. Indonesia's great frontier and migration policy. UFSI Rep. 1987;(30):1-11. View abstract.

McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. View abstract.

Messiha FS, Zaki NN. Effect of nutmeg on ethanol and d-amphetamine-produced alteration of locomotor activity in the mouse. Vet Hum Toxicol. 1984;26 Suppl 2:17-20. View abstract.

Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res. 2007;21(12):1142-5. View abstract.

Olajide OA, Ajayi FF, Ekhelar AI, et al. Biological effects of Myristica fragrans (nutmeg) extract. Phytother Res. 1999;13(4):344-5. View abstract.

Oswald EO, Fishbein L, Corbett BJ, Walker MP. Urinary excretion of tertiary amino methoxy methylenedioxy propiophenones as metabolites of myristicin in the rat and guinea pig. Biochim Biophys Acta. 1971;244(2):322-8.

Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. View abstract.

Park EY, Shin SM, Ma CJ, Kim YC, Kim SG. meso-dihydroguaiaretic acid from Machilus thunbergii down-regulates TGF-beta1 gene expression in activated hepatic stellate cells via inhibition of AP-1 activity. Planta Med. 2005;71(5):393-8. View abstract.

Parle M, Dhingra D, Kulkarni SK. Improvement of mouse memory by Myristica fragrans seeds. J Med Food. 2004;7(2):157-61. View abstract.

Payne RB. Nutmeg intoxication. N Engl J Med. 1963;269:36-9. View abstract.

Pecevski J, Savkovic D, Radivojevic D, Vuksanovic L. Effect of oil of nutmeg on the fertility and induction of meiotic chromosome rearrangements in mice and their first generation. Toxicol Lett. 1981;7(3):239-43. View abstract.

Qiu Q, Zhang G, Sun X, Liu X. [Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation]. Zhong Yao Cai. 2004;27(11):823-6. View abstract.

Quin GI, Fanning NF, Plunkett PK. Nutmeg intoxication. J Accid Emerg Med 1998;15:287-8. View abstract.

Ram A, Lauria P, Gupta R, Sharma VN. Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits. J Ethnopharmacol. 1996;55(1):49-53. View abstract.

Randerath K, Putman KL, Randerath E. Flavor constituents in cola drinks induce hepatic DNA adducts in adult and fetal mice. Biochem Biophys Res Commun. 1993;192(1):61-8. View abstract.

Rasheed A, Laekeman GM, Vlietinck AJ, et al. Pharmacological influence of nutmeg and nutmeg constituents on rabbit platelet function. Planta Med. 1984;50(3):222-6. View abstract.

Saleh M, Nabil Z, Mekkawy H, Abd Allah G. Acute and chronic effects of a nutmeg extract on the toad heart. Pharmacol Biochem Behav. 1989;32(1):83-6. View abstract.

Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. View abstract.

Scholefield JH. Nutmeg-an unusual overdose. Arch Emerg Med 1986;3:154-5. View abstract.

Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. View abstract.

Senthilkumar N, Varma P, Gurusubramanian G. Larvicidal and adulticidal activities of some medicinal plants against the malarial vector, Anopheles stephensi (Liston). Parasitol Res. 2009;104(2):237-44. View abstract.

Sharma M, Kumar M. Radioprotection of Swiss albino mice by Myristica fragrans houtt. J Radiat Res. 2007;48(2):135-41. View abstract.

Sherry CJ, Burnett RE. Enhancement of ethanol-induced sleep by whole oil of nutmeg. Experientia. 1978;34(4):492-3. View abstract.

Sherry CJ, Ray LE, Herron RE. The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans). J Ethnopharmacol. 1982;6(1):61-6. View abstract.

Shinohara C, Mori S, Ando T, Tsuji T. Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C. Biosci Biotechnol Biochem. 1999;63(8):1475-7. View abstract.

Shulgin AT. Possible implication of myristicin as a psychotropic substance. Nature. 1966;210(5034):380-4. View abstract.

Sohn JH, Han KL, Choo JH, Hwang JK. Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage. Biofactors. 2007;29(1):1-10. View abstract.

Sohn JH, Han KL, Kim JH, Rukayadi Y, Hwang JK. Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol Pharm Bull. 2008;31(2):273-7. View abstract.

Sonavane GS, Sarveiya VP, Kasture VS, Kasture SB. Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav. 2002;71(1-2):239-44. View abstract.

Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. View abstract.

Tabata, S., Kamimura, H., Ibe, A., Hashimoto, H., Iida, M., Tamura, Y., and Nishima, T. Aflatoxin contamination in foods and foodstuffs in Tokyo: 1986-1990. J AOAC Int. 1993;76(1):32-35. View abstract.

Tajuddin, Ahmad S, Latif A, Qasmi IA, Amin KM. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med. 2005;5:16. View absttract.

Tajuddin, Ahmad S, Latif A, Qasmi IA. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med. 2003;3:6. View abstract.

Takikawa A, Abe K, Yamamoto M, et al. Antimicrobial activity of nutmeg against Escherichia coli O157. J Biosci Bioeng. 2002;94(4):315-20. View abstract.

Takino M, Tanaka T, Yamaguchi K, Nakahara T. Atmospheric pressure photo-ionization liquid chromatography/mass spectrometric determination of aflatoxins in food. Food Addit Contam. 2004;21(1):76-84. View abstract.

Tezuka Y, Irikawa S, Kaneko T, et al. Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum. J Ethnopharmacol. 2001;77(2-3):209-17.

Uchibayashi M. [The nutmeg story]. Yakushigaku Zasshi. 2001;36(1):76-9. View abstract.

United States. Department of State. Bureau of Public Affairs. Grenada. Backgr Notes Ser. 1985:1-4. View abstract.

van den Akker TW, Roesyanto-Mahadi ID, van Toorenenbergen AW, van Joost T. Contact allergy to spices. Contact Dermatitis. 1990;22(5):267-72. View abstract.

Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol. 1994;42(2):117-24. View abstract.

Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. View abstract.

Wahab A, Ul Haq R, Ahmed A, Khan RA, Raza M. Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytother Res. 2009;23(2):153-8. View abstract.

Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90. View abstract.

Yang S, Na MK, Jang JP, et al. Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans. Phytother Res. 2006;20(8):680-2. View abstract.

Yang XW, Huang X, Ahmat M. [New neolignan from seed of Myristica fragrans]. Zhongguo Zhong Yao Za Zhi. 2008;33(4):397-402. View abstract.

Yanti, Rukayadi Y, Kim KH, Hwang JK. In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. Phytother Res. 2008;22(3):308-12. View abstract.

Yun CH, Lee HS, Lee HY, et al. Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin. Toxicol Lett. 2003;137(3):143-50. View abstract.

Zhou Y, Tan J. [Effect of different processing conditions on content of myrisiticin, volatile oil and fatty lipid in semen Myristicae]. Zhongguo Zhong Yao Za Zhi. 1998;23(4):217-9, 255. View abstract.

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