Other Name(s):

1,5-Dimethylhexylamine, 1,5-Diméthylhexylamine, 2-Amino-6-methylheptane, 2-Amino-6-méthylheptane, 2-Aminoisoheptane, 6-Methyl-2-heptylamine, 6-Méthyl-2-heptylamine, 6-methylheptan-2-amine, 6-méthylheptane-2-amine, Aconite Extract, Aconitum Kusnezoffii, Amidrine, DMHA, Extrait d’Aconit, Vaporpac.


Octodrine was originally used as drug for nasal congrestion. Today, octodrine is included as an ingredient in products used as dietary supplements to boost workout performance, "burn fat," or increase weight loss.

Some products claim that octodrine comes naturally from aconite plants, but there is no clear evidence that octodrine can be found in these plants. It is likely that octodrine found in dietary supplements is made in a laboratory rather than produced from natural sources.

Octodrine appears to be similar to another stimulant called dimethylamylamine (DMAA). DMAA has been removed from the market in certain countries due to safety concerns.

How does it work?

Octodrine is thought to have stimulant effects similar to decongestants such as pseudoephedrine, ephedrine, and others. Some promoters say that it is a safer alternative to ephedrine and dimethylamylamine. However, there is no scientific information to back up this claim.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate octodrine for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow

Side Effects

Octodrine is POSSIBLY UNSAFE when taken by mouth. Octodrine might have effects similar to dimethylamylamine (DMAA) which is another stimulant that might cause serious side effects, including heart attack and death.

Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking octodrine if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

High blood pressure: Octodrine might have stimulant effects and increase blood pressure. If you have high blood pressure, avoid taking octodrine.

Glaucoma: Octodrine might have stimulant effects and cause blood vessels to constrict. This could worsen some types of glaucoma. If you have glaucoma, avoid taking octodrine.

Irregular heartbeat (heart arrhythmia): Octodrine might have stimulant effects and cause a rapid heartbeat. This could worsen heart arrhythmias. If you have an irregular heartbeat, avoid taking octodrine.

Surgery: Octodrine might have stimulant effects, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking octodrine at least 2 weeks before a scheduled surgery.


Stimulant drugsInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Octodrine might also speed up the nervous system. Taking octodrine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with octodrine.

Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.


The appropriate dose of octodrine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for octodrine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


. Safety data sheet: 2-Amino-6-methylheptane. Fisher Scientific. Revised Feb 10, 2015. Available at: http://www.fishersci.com/shop/msdsproxy?productName=AC116301000&productDescription=2-AMINO-6-METHYLHEPTANE%2C. Accessed Sept 25, 2016.

Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.

Arkhipov A, Sirdaarta J, Matthews B, Cock IE. Metabolomic profiling of Kigelia Africana extracts with anti-cancer activity by high resolution tandem mass spectroscopy. Pharmacognosy Communications 2014;4(4):10-32.

Classification of 1,3-dimethylamylamine (DMAA). Health Canada, July 7, 2011.

DMAA Banned from 9 April 2012. Ministry of Health, New Zealand, March 23, 2012. Available at: http://www.health.govt.nz/news-media/news-items/dmaa-banned-9-april-2012

DMHA / 2-Aminoisoheptane / Octodrine: 2016's Stimulant. PricePlow Blog. Mar 22, 2016. Available at: https://blog.priceplow.com/dmha. Accessed Sept 25, 2016.

Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.

Fellows EJ. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther 1947;90(4):351-8. View abstract.

Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7. View abstract.

Hutcheon DE, McCullough L. The respiratory stimulant action of octylamines. Br J Pharmacol Chemother 1952;7(1):42-6. View abstract.

Kim K, Zilbermintz L, Martchenko M. Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans. Ann Clin Microbiol Antimicrob 2015;14:32. View abstract.

McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.

McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31.

Monroe RR, Drell HJ. Oral use of stimulants obtained from inhalers. J Am Med Assoc 1947; 135(14):909-15. View abstract.

Niu H, Cui P, Shi W, et al. Identification of anti-persister activity against uropathogenic Escherichia coli from a clinical drug library. Antibiotics (Basel) 2015;4(2):179-87. View abstract.

Rasmussen N, Keizers PH. History full circle: 'novel' sympathomimetics in supplements. Drug Test Anal 2016;8(3-4):283-6. View abstract.

Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).

Song Y, Zhang N, Shi S, et al. Large-scale qualitative and quantitative characterization of components in Shenfu injection by integrating hydrophilic interaction chromatography, reversed phase liquid chromatography, and tandem mass spectrometry. J Chromatogr A 2015;1407:106-18. View abstract.

Starling S. Synthetic geranium substance raises ephedra-like red flags. Nutraingredients-use.com, May 11, 2010. Available at: http://www.nutraingredients-usa.com/Industry/Synthetic-geranium-substance-raises-ephedra-like-red-flags. (Accessed 12 August 2011).

Sun A, Gao B, Ding X, et al. Quantitative and qualitative analysis of Aconitum alkaloids in raw and processed Chuanwu and Caowu by HPLC in combination with automated analytical system and ESI/MS/MS. J Anal Methods Chem 2012;2012:936131. View abstract.

Sun H, Wang A, Zhang A, et al. UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach. Phytochem Anal 2013;24(3):263-76. View abstract.

The World Anti-Doping Code. The 2010 Prohibited List International Standard. Word Anti-Doping Agency, September 19, 2009. Available at: http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/WADA_Prohibited_List_2010_EN.pdf

UPDATE to ALFOODACT 034-2011 and ALFOODACT 036-2011, and 041-2011 Dimethylamylamine (DMAA) Is Placed On Medical Hold Due To Possible Serious Adverse Health Effects. DLA Troop Support, December 30, 2011. Available at: http://www.dscp.dla.mil/subs/fso/alfood/2011/alf04411.pdf. (Accessed 4 January 2012).

Vorce SP, Holler JM, Cawrse BM, Magluilo J. Dimethylamylamine: A drug causing positive immunoassay results for amphetamines. J Anal Toxicol 2011;35:183-7. View abstract.

Wang B, Ji J, Zhao S, et al. An efficient high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry method to elaborate the changes of components between the raw and processed radix Aconitum kusnezoffii. Pharmacogn Mag 2016;12(45):4-8. View abstract.

Yang Y, Yin XJ, Guo HM, et al. Identification and comparative analysis of the major chemical constituents in the extracts of single fuzi herb and fuzi-gancao herb-pair by UFLC-IT-TOF/MS. Chin J Nat Med 2014;12(7):542-53. View abstract.

Zhang Q, Wang CH, Ma YM, et al. UPLC-ESI/MS determination of 17 active constituents in two categorized formulas of traditional Chinese medicine, Sanhuang Xiexin Tan and Fuzi Xiexin Tang: application in comparing the differences in decoctions and macerations. Biomed Chromatogr 2013;27(8):1079-88. View abstract.

Health Solutions From Our Sponsors