Acides Gras Essentiels N-6, Acides Gras Oméga-6, Acides Gras Omégas 6, Acides Gras Polyinsaturés, Acidos Grasos Omega 6, AGE, AGPI, Huiles d'Oméga 6, N-6, N-6 EFAs, N-6 Essential Fatty Acids, Omega 6, Omega-6 Polyunsaturated Fatty Acids, Omega 6 Oils, Polyunsaturated Fatty Acids, PUFAs.
Omega-6 fatty acids are types of fats. Some types are found in vegetable oils, including corn, evening primrose seed, safflower, and soybean oils. Other types of omega-6 fatty acids are found in black currant seed, borage seed, and evening primrose oils.
Omega-6 fatty acids are used for many conditions, but so far, the best information that science can provide is that putting arachidonic acid, a particular omega-6 fatty acid, doesn't improve infant development. Not enough research has been done on omega-6 fatty acids to judge whether or not they are effective for other uses.
Omega-6 fatty acids are used for reducing the risk of heart disease, lowering total cholesterol levels, lowering "bad" (LDL) cholesterol levels, raising "good" (HDL) cholesterol levels, and reducing cancer risk.
Most of the information we have on omega-6 fatty acid supplements comes from studying specific omega-6 fatty acids or plant oils containing omega-6 fatty acids. See the separate listing for evening primrose oil.
How does it work?
There isn't enough information available to know how omega-6 fatty acids work.
Possibly Ineffective for...
Insufficient Evidence to Rate Effectiveness for...
- Attention deficit-hyperactivity disorder (ADHD). Early research suggests that taking a combination of omega-3 and omega-6 fatty acids twice daily for 3-6 months does not improve symptoms of ADHD in most children.
- Eyelid swelling due to a problem with oil glands in the eyelids. Early research suggests that taking a specific product (Medilar Fidia Oftal Bausch & Laomb Pharmaceuticals) that contains omega-6 fatty acids once daily for 180 days along with cleaning the eyelids can improve cloudiness in the eyes, blockage of the oil glands, and eyelid swelling in people with an eyelid swelling due to a problem with oil glands in the eyelid.
- Developmental coordination disorder (DCD). Early research suggests that taking a combination of omega-6 and omega-3 fatty acids for 3 months can improve reading, spelling, and behavior, but not coordination or movement in children with DCD.
- Laser eye surgery. Early research suggests that taking a tablet that contains an omega-6 fatty acid, as well as beta-carotene and other ingredients, can improve tear production and improve eye healing after laser eye surgery.
- Improving mental development or growth in infants.Adding arachidonic acid (an omega-6 fatty acid) to infant formula does not seem to improve mental development or growth in infants up to 18 months old. Infants fed formula with arachidonic acid and docosahexaenoic acid for the first 4 months of life did not have higher IQ scores, but were able to process information more quickly.
- Respiratory illness in infants. Early research suggests that infants fed formula supplemented with arachidonic acid and docosahexaenoic acid for the first year of life had a lower risk of respiratory illness.
- Diarrhea in infants. Early research suggests that infants fed formula supplemented with arachidonic acid and docosahexaenoic acid for the first year of life had a lower risk of diarrhea.
- Reducing the risk of heart disease.
- Lowering bad cholesterol levels (LDL).
- Increasing good cholesterol levels (HDL).
- Reducing the risk of cancer.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Omega-6 fatty acids are LIKELY SAFE when consumed by adults and children over the age of 12 months as part of the diet in amounts between 5% and 10% of daily calories. However, there is not enough reliable information available to know if omega-6 fatty acids are safe to use as medicine.
The appropriate dose of omega-6 fatty acids depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for omega-6 fatty acids. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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Ailhaud, G. Omega-6 fatty acids and excessive adipose tissue development. World Rev Nutr Diet. 2008;98:51-61. View abstract.
Alexander, J. W., Goodman, H. R., Succop, P., Light, J. A., Kuo, P. C., Moser, A. B., James, J. H., and Woodle, E. S. Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. Exp Clin Transplant. 2008;6(2):118-126. View abstract.
Almqvist, C., Garden, F., Xuan, W., Mihrshahi, S., Leeder, S. R., Oddy, W., Webb, K., and Marks, G. B. Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J Allergy Clin Immunol. 2007;119(6):1438-1444. View abstract.
An, W. S., Kim, S. E., Kim, K. H., Lee, S., Park, Y., Kim, H. J., and Vaziri, N. D. Comparison of fatty acid contents of erythrocyte membrane in hemodialysis and peritoneal dialysis patients. J Ren Nutr 2009;19(4):267-274. View abstract.
Anes, E. and Jordao, L. Trick-or-treat: dietary lipids and host resistance to infectious disease. Mini.Rev Med Chem 2008;8(14):1452-1458. View abstract.
Arterburn, L. M., Boswell, K. D., Henwood, S. M., and Kyle, D. J. A developmental safety study in rats using DHA- and ARA-rich single-cell oils. Food Chem Toxicol. 2000;38(9):763-771. View abstract.
Assies, J., Lok, A., Bockting, C. L., Weverling, G. J., Lieverse, R., Visser, I., Abeling, N. G., Duran, M., and Schene, A. H. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot.Essent.Fatty Acids 2004;70(4):349-356. View abstract.
Aupperle, R. L., Denney, D. R., Lynch, S. G., Carlson, S. E., and Sullivan, D. K. Omega-3 fatty acids and multiple sclerosis: relationship to depression. J Behav Med 2008;31(2):127-135. View abstract.
Bommareddy, A., Arasada, B. L., Mathees, D. P., and Dwivedi, C. Chemopreventive effects of dietary flaxseed on colon tumor development. Nutr Cancer 2006;54(2):216-222. View abstract.
Carrillo-Tripp, M. and Feller, S. E. Evidence for a mechanism by which omega-3 polyunsaturated lipids may affect membrane protein function. Biochemistry 8-2-2005;44(30):10164-10169. View abstract.
Charnock, J. S., Abeywardena, M. Y., McMurchie, E. J., and Russell, G. R. The composition of cardiac phospholipids in rats fed different lipid supplements. Lipids 1984;19(3):206-213. View abstract.
Chevillotte, E., Rieusset, J., Roques, M., Desage, M., and Vidal, H. The regulation of uncoupling protein-2 gene expression by omega-6 polyunsaturated fatty acids in human skeletal muscle cells involves multiple pathways, including the nuclear receptor peroxisome proliferator-activated receptor beta. J Biol Chem 4-6-2001;276(14):10853-10860. View abstract.
Chiplonkar, S. A., Agte, V. V., Tarwadi, K. V., Paknikar, K. M., and Diwate, U. P. Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll.Nutr 2004;23(3):239-247. View abstract.
Chung, F. L., Pan, J., Choudhury, S., Roy, R., Hu, W., and Tang, M. S. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat.Res 10-29-2003;531(1-2):25-36. View abstract.
Colin, A., Reggers, J., Castronovo, V., and Ansseau, M. [Lipids, depression and suicide]. Encephale 2003;29(1):49-58. View abstract.
Colter, A. L., Cutler, C., and Meckling, K. A. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008;7:8. View abstract.
Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., and Muldoon, M. F. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom.Med. 2007;69(9):932-934. View abstract.
Cunnane, S. C. Problems with essential fatty acids: time for a new paradigm? Prog.Lipid Res 2003;42(6):544-568. View abstract.
Cyhlarova, E., Bell, J. G., Dick, J. R., Mackinlay, E. E., Stein, J. F., and Richardson, A. J. Membrane fatty acids, reading and spelling in dyslexic and non-dyslexic adults. Eur.Neuropsychopharmacol. 1-15-2007;17(2):116-121. View abstract.
Darios, F. and Davletov, B. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature 4-6-2006;440(7085):813-817. View abstract.
de Alaniz, M. J., de Gomez Dumm, I. N., and Brenner, R. R. Effect of fatty acids of omega 6 series on the biosynthesis of arachidonic acid in HTC cells. Mol.Cell Biochem. 1984;64(1):31-37. View abstract.
de, Lorgeril M. Essential polyunsaturated fatty acids, inflammation, atherosclerosis and cardiovascular diseases. Subcell.Biochem. 2007;42:283-297. View abstract.
Diamond, I. R., Sterescu, A., Pencharz, P. B., and Wales, P. W. The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease. Pediatr Surg.Int 2008;24(7):773-778. View abstract.
Dimitrova-Sumkovska, J., Dosic-Markovska, B., Zafirova-Roganovic, D., and Anastasovska, V. Effects of different dietary fatty acid supplements upon lipoprotein metabolism and lipid peroxides production in hyperlipidemic rats. Prilozi. 2006;27(1):67-86. View abstract.
Dubnov, G. and Berry, E. M. Omega-6 fatty acids and coronary artery disease: the pros and cons. Curr Atheroscler.Rep 2004;6(6):441-446. View abstract.
Dumelin, E. E. and Tappel, A. L. Hydrocarbon gases produced during in vitro peroxidation of polyunsaturated fatty acids and decomposition of preformed hydroperoxides. Lipids 1977;12(11):894-900. View abstract.
Eivindson, M., Gronbaek, H., Nielsen, J. N., Frystyk, J., Flyvbjerg, A., Jorgensen, L., Vind, I., Munkholm, P., Jensen, S., Brandslund, I., and Hey, H. Insulin-like growth factors (IGFs) and IGF binding proteins in active Crohn's disease treated with omega-3 or omega-6 fatty acids and corticosteroids. Scand.J Gastroenterol 2005;40(10):1214-1221. View abstract.
Esterbauer, H. Cytotoxicity and genotoxicity of lipid-oxidation products. Am J Clin Nutr 1993;57(5 Suppl):779S-785S. View abstract.
Farinotti, M., Simi, S., Di, Pietrantonj C., McDowell, N., Brait, L., Lupo, D., and Filippini, G. Dietary interventions for multiple sclerosis. Cochrane.Database.Syst.Rev 2007;(1):CD004192. View abstract.
Gercek, A., Yildirim, O., Konya, D., Bozkurt, S., Ozgen, S., Kilic, T., Sav, A., and Pamir, N. Effects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone. JPEN J Parenter.Enteral Nutr 2007;31(3):161-166. View abstract.
Gibson, R. A., Teubner, J. K., Haines, K., Cooper, D. M., and Davidson, G. P. Relationships between pulmonary function and plasma fatty acid levels in cystic fibrosis patients. J Pediatr Gastroenterol Nutr 1986;5(3):408-415. View abstract.
Godley, P. A., Campbell, M. K., Gallagher, P., Martinson, F. E., Mohler, J. L., and Sandler, R. S. Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. Cancer Epidemiol.Biomarkers Prev. 1996;5(11):889-895. View abstract.
Grimble, R. F. Immunonutrition. Curr Opin.Gastroenterol 2005;21(2):216-222. View abstract.
Gudbjarnason, S., Benediktsdottir, V. E., and Gudmundsdottir, E. Balance between omega 3 and omega 6 fatty acids in heart muscle in relation to diet, stress and ageing. World Rev Nutr Diet. 1991;66:292-305. View abstract.
Hakkarainen, R., Partonen, T., Haukka, J., Virtamo, J., Albanes, D., and Lonnqvist, J. Food and nutrient intake in relation to mental wellbeing. Nutr J 9-13-2004;3:14. View abstract.
Harbige, L. S., Layward, L., Morris-Downes, M. M., Dumonde, D. C., and Amor, S. The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production. Clin Exp.Immunol. 2000;122(3):445-452. View abstract.
Harris, W. S. Chylomicron metabolism and omega 3 and omega 6 fatty acids. World Rev Nutr Diet. 1994;76:23-25. View abstract.
Harris, W. S., Assaad, B., and Poston, W. C. Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease. Am J Cardiol. 8-21-2006;98(4A):19i-26i. View abstract.
Harris, W. S., Mozaffarian, D., Rimm, E., Kris-Etherton, P., Rudel, L. L., Appel, L. J., Engler, M. M., Engler, M. B., and Sacks, F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 2-17-2009;119(6):902-907. View abstract.
Hennig, B., Meerarani, P., Ramadass, P., Watkins, B. A., and Toborek, M. Fatty acid-mediated activation of vascular endothelial cells. Metabolism 2000;49(8):1006-1013. View abstract.
Hennig, B., Toborek, M., and McClain, C. J. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll.Nutr 2001;20(2 Suppl):97-105. View abstract.
Hodge, L., Salome, C. M., Hughes, J. M., Liu-Brennan, D., Rimmer, J., Allman, M., Pang, D., Armour, C., and Woolcock, A. J. Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. Eur Respir.J 1998;11(2):361-365. View abstract.
Huang, Y. S., Dufour, R., and Davignon, J. Effect of methyl linoleate administration on phospholipid fatty acid composition and osmotic fragility of erythrocytes in essential fatty acid deficient rats. J Am Coll.Nutr 1983;2(1):55-61. View abstract.
Huang, Y. S., Martineau, A., Falardeau, P., and Davignon, J. Fatty acid composition of tissue phospholipids and prostaglandin excretion in hyperlipidemia induced in rats by implantation of the mammotropic pituitary tumor MtT-F4. Lipids 1983;18(6):412-422. View abstract.
Hughes-Fulford, M., Tjandrawinata, R. R., Li, C. F., and Sayyah, S. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis 2005;26(9):1520-1526. View abstract.
Humbert, P. [Functional consequences of cutaneous lipid perturbation]. Pathol.Biol (Paris) 2003;51(5):271-274. View abstract.
Inoue, M., Murase, S., and Okuyama, H. Acyl coenzyme a:phospholipid acyltransferases in porcine platelets discriminate between omega-3 and omega-6 unsaturated fatty acids. Arch.Biochem.Biophys. 5-15-1984;231(1):29-37. View abstract.
Johnson, M., Ostlund, S., Fransson, G., Kadesjo, B., and Gillberg, C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J.Atten.Disord. 2009;12(5):394-401. View abstract.
Jones, R., Adel-Alvarez, L. A., Alvarez, O. R., Broaddus, R., and Das, S. Arachidonic acid and colorectal carcinogenesis. Mol.Cell Biochem. 2003;253(1-2):141-149. View abstract.
Kafrawy, O., Zerouga, M., Stillwell, W., and Jenski, L. J. Docosahexaenoic acid in phosphatidylcholine mediates cytotoxicity more effectively than other omega-3 and omega-6 fatty acids. Cancer Lett. 10-23-1998;132(1-2):23-29. View abstract.
Kang, E. S., Olson, G., Jabbour, J. T., Solomon, S. S., Heimberg, M., Sabesin, S., and Griffith, J. F. Development of encephalopathic features similar to Reye syndrome in rabbits. Proc.Natl.Acad.Sci.U.S.A 1984;81(19):6169-6173. View abstract.
King, V. R., Huang, W. L., Dyall, S. C., Curran, O. E., Priestley, J. V., and Michael-Titus, A. T. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci. 4-26-2006;26(17):4672-4680. View abstract.
Koletzko, B., Abiodun, P. O., Laryea, M. D., Schmid, S., and Bremer, H. J. Comparison of fatty acid composition of plasma lipid fractions in well-nourished Nigerian and German infants and toddlers. J Pediatr Gastroenterol Nutr 1986;5(4):581-585. View abstract.
Laidler, P., Dulinska, J., and Mrozicki, S. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? Arch.Biochem.Biophys. 6-1-2007;462(1):1-12. View abstract.
Lauretani, F., Bandinelli, S., Bartali, B., Cherubini, A., Iorio, A. D., Ble, A., Giacomini, V., Corsi, A. M., Guralnik, J. M., and Ferrucci, L. Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. Eur.J Neurol. 2007;14(7):801-808. View abstract.
Lemoyne, M., Van, Gossum A., Kurian, R., Ostro, M., Axler, J., and Jeejeebhoy, K. N. Breath pentane analysis as an index of lipid peroxidation: a functional test of vitamin E status. Am J Clin Nutr 1987;46(2):267-272. View abstract.
Levy, E. Essentiality of omega-3 and omega-6 fatty acids for efficient liver sterol metabolism. Can.J Cardiol. 1995;11 Suppl G:29G-35G. View abstract.
Madani, S., Hichami, A., Cherkaoui-Malki, M., and Khan, N. A. Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. J Biol Chem 1-9-2004;279(2):1176-1183. View abstract.
Mahmud, N. and Weir, D. G. The urban diet and Crohn's disease: is there a relationship? Eur.J Gastroenterol Hepatol. 2001;13(2):93-95. View abstract.
Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., Flouri, S., Mantzoros, C., and Kafatos, A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol.Biochem.Behav. 2006;85(2):474-479. View abstract.
Maple, C., McLaren, M., Bancroft, A., Ho, M., and Belch, J. J. Dietary supplementation with omega 3 and omega 6 fatty acids reduces induced white blood cell aggregation in healthy volunteers. Prostaglandins Leukot.Essent.Fatty Acids 1998;58(5):365-368. View abstract.
Marantos, C., Mukaro, V., Ferrante, J., Hii, C., and Ferrante, A. Inhibition of the lipopolysaccharide-induced stimulation of the members of the MAPK family in human monocytes/macrophages by 4-hydroxynonenal, a product of oxidized omega-6 fatty acids. Am J Pathol. 2008;173(4):1057-1066. View abstract.
Margolin, G., Huster, G., Glueck, C. J., Speirs, J., Vandegrift, J., Illig, E., Wu, J., Streicher, P., and Tracy, T. Blood pressure lowering in elderly subjects: a double-blind crossover study of omega-3 and omega-6 fatty acids. Am J Clin Nutr 1991;53(2):562-572. View abstract.
Martinez, M. and Ballabriga, A. Effects of parenteral nutrition with high doses of linoleate on the developing human liver and brain. Lipids 1987;22(3):133-138. View abstract.
Martinez-Ramirez, M. J., Palma, S., Martinez-Gonzalez, M. A., Delgado-Martinez, A. D., de la Fuente, C., and Delgado-Rodriguez, M. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur.J Clin Nutr 2007;61(9):1114-1120. View abstract.
Mayer, K., Schmidt, R., Muhly-Reinholz, M., Bogeholz, T., Gokorsch, S., Grimminger, F., and Seeger, W. In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFalpha impact of omega-3 versus omega-6 fatty acids. J Lipid Res 2002;43(6):944-951. View abstract.
McKenzie, K. E., Bandyopadhyay, G. K., Imagawa, W., Sun, K., and Nandi, S. Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells. Prostaglandins Leukot.Essent.Fatty Acids 1994;51(6):437-443. View abstract.
Melnik, B. and Plewig, G. Are disturbances of omega-6-fatty acid metabolism involved in the pathogenesis of atopic dermatitis? Acta Derm.Venereol.Suppl (Stockh) 1992;176:77-85. View abstract.
Menendez, J. A., Ropero, S., Mehmi, I., Atlas, E., Colomer, R., and Lupu, R. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. Int J Oncol. 2004;24(6):1369-1383. View abstract.
Metzner, C. and Luder, W. [Plant omega 3- and omega 6-fatty acids]. Pharm.Unserer Zeit 2007;36(2):134-141. View abstract.
Mickleborough, T. and Gotshall, R. Dietary components with demonstrated effectiveness in decreasing the severity of exercise-induced asthma. Sports Med 2003;33(9):671-681. View abstract.
Mills, D. E. Dietary omega 3 and omega 6 fatty acids and cardiovascular responses to pressor and depressor stimuli. World Rev Nutr Diet. 1991;66:349-357. View abstract.
Mohler, E. R., III, Reaven, P., Stegner, J. E., Fineberg, N. S., and Hathaway, D. R. Gas chromatographic method using photoionization detection for the determination of breath pentane. J Chromatogr.B Biomed.Appl. 10-25-1996;685(2):201-209. View abstract.
Moore, S. A., Yoder, E., and Spector, A. A. Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. J Neurochem. 1990;55(2):391-402. View abstract.
Munoz, S. E., Piegari, M., Guzman, C. A., and Eynard, A. R. Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. Nutrition 1999;15(3):208-212. View abstract.
Murphy, M. G. and Byczko, Z. Effects of membrane polyunsaturated fatty acids on adenosine receptor function in intact N1E-115 neuroblastoma cells. Biochem.Cell Biol 1990;68(1):392-395. View abstract.
Murray, M. J., Kanazi, G., Moukabary, K., Tazelaar, H. D., and DeMichele, S. J. Effects of eicosapentaenoic and gamma-linolenic acids (dietary lipids) on pulmonary surfactant composition and function during porcine endotoxemia. Chest 2000;117(6):1720-1727. View abstract.
Nielsen, A. A., Jorgensen, L. G., Nielsen, J. N., Eivindson, M., Gronbaek, H., Vind, I., Hougaard, D. M., Skogstrand, K., Jensen, S., Munkholm, P., Brandslund, I., and Hey, H. Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids. Aliment.Pharmacol.Ther. 2005;22(11-12):1121-1128. View abstract.
Nielsen, A. A., Nielsen, J. N., Gronbaek, H., Eivindson, M., Vind, I., Munkholm, P., Brandslund, I., and Hey, H. Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion 2007;75(1):10-16. View abstract.
Nikkari, T. Serum fatty acids and coronary heart disease in Finnish populations. Prog.Lipid Res 1986;25(1-4):437-450. View abstract.
Novak, E. M., Dyer, R. A., and Innis, S. M. High dietary omega-6 fatty acids contribute to reduced docosahexaenoic acid in the developing brain and inhibit secondary neurite growth. Brain Res 10-27-2008;1237:136-145. View abstract.
O'Connor, T. P., Roebuck, B. D., Peterson, F. J., Lokesh, B., Kinsella, J. E., and Campbell, T. C. Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas. J Natl.Cancer Inst. 6-7-1989;81(11):858-863. View abstract.
Okuyama, H., Ichikawa, Y., Sun, Y., Hamazaki, T., and Lands, W. E. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. World Rev Nutr Diet. 2007;96:143-149. View abstract.
Palmblad, J., Wannemacher, R. W., Salem, N., Jr., Kuhns, D. B., and Wright, D. G. Essential fatty acid deficiency and neutrophil function: studies of lipid-free total parenteral nutrition in monkeys. J Lab Clin Med 1988;111(6):634-644. View abstract.
Palmer, R. M. and Wahle, K. W. Protein synthesis and degradation in isolated muscle. Effect of omega 3 and omega 6 fatty acids. Biochem.J 3-1-1987;242(2):615-618. View abstract.
Pan, J. and Chung, F. L. Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem Res Toxicol. 2002;15(3):367-372. View abstract.
Peck, M. D., Mantero-Atienza, E., Miguez-Burbano, M. J., Lu, Y., Fletcher, M. A., Shor-Posner, G., and Baum, M. K. The esterified plasma fatty acid profile is altered in early HIV-1 infection. Lipids 1993;28(7):593-597. View abstract.
Pinna, A., Piccinini, P., and Carta, F. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. Cornea 2007;26(3):260-264. View abstract.
Querques, G., Russo, V., Barone, A., Iaculli, C., and Delle, Noci N. [Efficacy of omega-6 essential fatty acid treatment before and after photorefractive keratectomy]. J Fr Ophtalmol. 2008;31(3):282-286. View abstract.
Rao, R. and Lokesh, B. R. Nutritional evaluation of structured lipid containing omega 6 fatty acid synthesized from coconut oil in rats. Mol.Cell Biochem. 2003;248(1-2):25-33. View abstract.
Rashid, S., Jin, Y., Ecoiffier, T., Barabino, S., Schaumberg, D. A., and Dana, M. R. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch.Ophthalmol. 2008;126(2):219-225. View abstract.
Raz, R. and Gabis, L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev.Med Child Neurol. 2009;51(8):580-592. View abstract.
Richardson, A. J., Cyhlarova, E., and Ross, M. A. Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot.Essent.Fatty Acids 2003;69(6):461-466. View abstract.
Sauerwald, T. U., Hachey, D. L., Jensen, C. L., Chen, H., Anderson, R. E., and Heird, W. C. Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. Pediatr Res 1997;41(2):183-187. View abstract.
Seti, H., Leikin-Frenkel, A., and Werner, H. Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells. Arch.Physiol Biochem. 2009;115(3):127-136. View abstract.
Siguel, E. N. and Lerman, R. H. Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. Metabolism 1994;43(8):982-993. View abstract.
Simopoulos, A. P. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed.Pharmacother. 2006;60(9):502-507. View abstract.
Simopoulos, A. P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp.Biol Med (Maywood.) 2008;233(6):674-688. View abstract.
Simopoulos, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed.Pharmacother. 2002;56(8):365-379. View abstract.
Simopoulos, A. P. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac.J Clin Nutr 2008;17 Suppl 1:131-134. View abstract.
Singh, B., Lauzon, J., Venkatraman, J., Thomson, A. B., Rajotte, R. V., and Clandinin, M. T. Effect of high/low dietary linoleic acid levels on the function and fatty acid composition of T-lymphocytes of normal and diabetic rats. Diabetes Res 1988;8(3):129-134. View abstract.
Sobczak, S., Honig, A., Christophe, A., Maes, M., Helsdingen, R. W., De Vriese, S. A., and Riedel, W. J. Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients. Psychol.Med 2004;34(1):103-112. View abstract.
Socha, P., Koletzko, B., Pawlowska, J., and Socha, J. Essential fatty acid status in children with cholestasis, in relation to serum bilirubin concentration. J Pediatr 1997;131(5):700-706. View abstract.
Socha, P., Koletzko, B., Swiatkowska, E., Pawlowska, J., Stolarczyk, A., and Socha, J. Essential fatty acid metabolism in infants with cholestasis. Acta Paediatr. 1998;87(3):278-283. View abstract.
Sonestedt, E., Gullberg, B., and Wirfalt, E. Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer. Public Health Nutr 2007;10(8):769-779. View abstract.
Stevens, L. J., Zentall, S. S., Abate, M. L., Kuczek, T., and Burgess, J. R. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav. 1996;59(4-5):915-920. View abstract.
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., and Kraegen, E. W. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 1991;40(2):280-289. View abstract.
Stroh, S. and Elmadfa, I. [In vitro studies of the effect of different mixture proportions of omega-3 and omega-6 fatty acids on thrombocyte aggregation and thromboxane synthesis in human thrombocytes]. Z.Ernahrungswiss. 1991;30(3):192-200. View abstract.
Suresh, Y. and Das, U. N. Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus: effect of omega-6 fatty acids. Nutrition 2003;19(2):93-114. View abstract.
Tanaka, T., Shen, J., Abecasis, G. R., Kisialiou, A., Ordovas, J. M., Guralnik, J. M., Singleton, A., Bandinelli, S., Cherubini, A., Arnett, D., Tsai, M. Y., and Ferrucci, L. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS.Genet. 2009;5(1):e1000338. View abstract.
Tattersall, A. L. and Wilkins, R. J. Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. Pflugers Arch. 2008;456(3):501-506. View abstract.
Timur, S., Onal, S., Akyilmaz, E., and Telefoncu, A. An enzyme electrode based on lipoxygenase immobilized in gelatin for selective determination of essential fatty acids. Artif.Cells Blood Substit.Immobil.Biotechnol. 2003;31(3):329-337. View abstract.
Tribole, E. What happened to do no harm? The issue of dietary omega-6 fatty acids. Prostaglandins Leukot.Essent.Fatty Acids 2009;80(1):78-79. View abstract.
Tso, P. and Hayashi, H. The physiology and regulation of the intestinal absorption and transport of omega-3 and omega-6 fatty acids. Adv.Prostaglandin Thromboxane Leukot.Res 1989;19:623-626. View abstract.
Ventura, H. O., Milani, R. V., Lavie, C. J., Smart, F. W., Stapleton, D. D., Toups, T. S., and Price, H. L. Cyclosporine-induced hypertension. Efficacy of omega-3 fatty acids in patients after cardiac transplantation. Circulation 1993;88(5 Pt 2):II281-II285. View abstract.
Yamada, T., Strong, J. P., Ishii, T., Ueno, T., Koyama, M., Wagayama, H., Shimizu, A., Sakai, T., Malcom, G. T., and Guzman, M. A. Atherosclerosis and omega-3 fatty acids in the populations of a fishing village and a farming village in Japan. Atherosclerosis 2000;153(2):469-481. View abstract.
Yeh, E., Wood, R. D., and Squires, E. J. Influence of plasma lipid composition on activity of Factors V, VII and X in Single Comb White Leghorn and Fatty Liver Haemorrhagic Syndrome-susceptible laying hens. Br.Poult.Sci. 2008;49(6):760-769. View abstract.
Zhou, S. and Decker, E. A. Ability of amino acids, dipeptides, polyamines, and sulfhydryls to quench hexanal, a saturated aldehydic lipid oxidation product. J Agric.Food Chem 1999;47(5):1932-1936. View abstract.
Andrioli G, Carletto A, Guarini P, et al. Differential effects of dietary supplementation with fish oil or soy lecithin on human platelet adhesion. Thromb Haemost 1999;82:1522-7. View abstract.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.nap.edu/books/0309085373/html/.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate. Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/books/0309069351/html/
Gibson RA. Long-chain polyunsaturated fatty acids and infant development (editorial). Lancet 1999;354:1919.
Godley PA. Essential fatty acid consumption and risk of breast cancer. Breast Cancer Res Treat 1995;35:91-5. View abstract.
Harvei S, Bjerve KS, Tretli S, et al. Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. Int J Cancer 1997;71:545-51. View abstract.
Lapillonne A, Pastor N, Zhuang W, Scalabrin DMF. Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life. BMC Pediatr. 2014;14:168. View abstract.
Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 1993;119:867-73. View abstract.
Lucas A, Stafford M, Morley R, et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomized trial. Lancet 1999;354:1948-54. View abstract.
Malloy MJ, Kane JP. Agents used in hyperlipidemia. In: B. Katzung, ed. Basic and Clinical Pharmacology. 4th ed. Norwald, CT: Appleton and Lange, 1989.
Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risk. Prostate 2001;47:262-8. View abstract.
Noguchi M, Rose DP, Earashi M, Miyazaki I. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 1995;52:265-71. View abstract.
Richardson AJ, Montgomery P. The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005;115:1360-6. View abstract.
Rose DP. The mechanistic rationale in support of dietary cancer prevention. Prev Med 1996;25:34-7. View abstract.
Taha AY, Cheon Y, Faurot KF, et al. Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools. Prostaglandins Leukot Essen Fatty Acids. 2014;90(5):151-7.View abstract.
Willatts P, Forsyth S, Agostoni C, Casaer P, Riva, E, Boehm G. Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. Am J Clin Nutr. 2013;98(suppl):536S-42S. View abstract.