Opium Antidote

Other Name(s):

Antidote à l'Opium, Antidote d'Opium, Antídoto de Opio, Combretum, Combretum micranthum, Jungle Weed.


The leaf and stem of the plant Combretum micranthum are used to make medicine. This medicine is known as opium antidote.

People take opium antidote for gallbladder disease, upset stomach, and liver disease.

Opium antidote is no longer used by itself. It is used only in combination preparations.

How does it work?

Opium antidote might stimulate bile flow, a substance that is important in digestion.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Gallbladder disease.
  • Upset stomach.
  • Liver disease.
  • Other conditions.
More evidence is needed to rate the effectiveness of opium antidote for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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Side Effects

There isn't enough information available to know if opium antidote is safe.

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of opium antidote during pregnancy and breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of opium antidote depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for opium antidote. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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Reviewed on 6/14/2021

Ferrea G, Canessa A, Sampietro F, et al. In vitro activity of a Combretum micranthum extract against herpes simplex virus types 1 and 2. Antiviral Res 1993;21:317-25. View abstract.

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