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Paget Disease (cont.)

What Are Risk Factors for Paget’s Disease?

Being over 55 years of age is a risk factor for Paget’s disease. Certain genes have been identified that increase the risk of Paget’s disease. Paget’s disease is common in England, Scotland, Central Europe, and Greece, as well as in countries and cities settled by European immigrants, such as those in Australia, Canada, and the United States.

What Are Signs and Symptoms of Paget's Disease?

Most people with Paget's disease do not have symptoms. It is often discovered as an incidental finding on routine X-ray films or blood tests.

When symptoms do occur, the most common ones include pain, commonly joint pain, hip pain, neck pain, and low back pain. Other less common symptoms include fractures, bowing deformities of the bones (such as bowlegs), hearing loss, headaches, and muscle weakness. Pagetic bone contains numerous blood vessels, so a traumatic fracture through pagetic bone may result in significant blood loss. A patient can rarely develop congestive heart failure because of the increased blood flow. Increased calcium levels from the bone remodeling process can cause kidney stones.

Fractures and bowing deformities can occur because the increased rate of remodeling caused by Paget's disease makes the bone weaker, predisposing patients to fractures or deformity. Hearing loss can result from involvement of the small bones of the inner ear. Headaches result from involvement of the skull and facial bones. Muscle weakness can occur if the spine is involved, leading to stenosis or a narrowing of the spinal canal and pinching of the spinal cord and nerve roots.

Medically Reviewed by a Doctor on 10/27/2016

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Paget Disease »

Paget's disease (Paget disease), characterized by excessive and abnormal remodeling of bone, is a common disorder in middle-aged and elderly patients.

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