Doctor's Notes on Paget's Disease
Paget’s disease (also termed osteitis deformans) that is a disorder that affects the normal bone remodeling process. Patients have accelerated bone resorption and new bone formation that results in abnormal bone that is weaker, larger and more fragile than normal. Many people have no symptoms; the disease is found incidentally in an x-ray ordered for another reason. When signs and symptoms do occur, the most common is pain (joint, hip, neck, and low back). Less common symptoms include fractures, bowing of leg bones, hearing loss, headaches and muscle weakness.
The cause of Paget’s disease is uncertain; some researchers suggest several viral causes but the theories are unproven; others suggest a possible genetic link.
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Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.