Symptoms and Signs of Premenstrual Dysphoric Disorder (PMDD)

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Medically Reviewed on 3/11/2019

Doctor's Notes on Premenstrual Dysphoric Disorder (PMDD)

Premenstrual dysphoric Disorder (PMMD) is the severe form of premenstrual syndrome (PMS). The signs and symptoms are the same as for PMS, but they are severe enough to interfere with daily living and often need physician -directed treatment. Premenstrual syndrome (also termed PMS) is a syndrome that has monthly cycles of symptom changes in mood and behavior and/or physical functioning. Signs and symptoms of mood changes include anxiety, nervousness, mood swings, irritability, depression, forgetfulness, confusion, insomnia, and/or hostility. Behavior signs and symptoms include increased eating, cravings for sweets, crying, poor concentration and sensitivity to noise changes and alcohol tolerance. Physical function signs and symptoms include headache, heart palpitations, fatigue, dizziness, weight gain, bloating, breast swelling and/or tenderness, constipation or diarrhea. The syndrome usually occurs immediately after an egg is released from the ovary and may last from day 14 three day 28 for normal menstrual cycle with day one being that her period starts. Some individuals may have signs and symptoms extend into the period. Most women that have PMS have mild enough symptoms that they may treat them at home; when the above symptoms become severe enough to interfere with daily living, the patient has premenstrual dysphoric disorder (PMDD). PMMD may lead to severe depression and suicidal thoughts (a medical emergency).

PMMD is thought to be caused by the complex changing of hormone levels during the luteal phase of the menstrual cycle; for example, serotonin, the brain chemical that has many functions including mood control and sensitivity to pain, are reduced in some women with PMS and PMMD.

Premenstrual Dysphoric Disorder (PMDD) - Test Your IQ of Women's Health Quiz


Premenstrual dysphoric disorder is a severe form of premenstrual syndrome.

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Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.