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Rheumatoid Arthritis (cont.)

What Are Complications of Rheumatoid Arthritis?

Common complications of rheumatoid arthritis include the following:

  • Peripheral neuropathy and carpal tunnel syndrome: This condition results from damage to nerves, most often those in the hands and feet. It can result in tingling, numbness, or burning.
  • Anemia: This is a low level of hemoglobin, a protein in the blood that carries essential oxygen to cells and tissues. Symptoms include weakness, low energy, pallor, and shortness of breath.
  • Scleritis: This is a serious inflammation of the blood vessels in the white portion (sclera) of the eye that can damage the eyes and impair vision.
  • Infections: People with rheumatoid arthritis have a higher risk for infections. This is due partly to the abnormal immune system in rheumatoid arthritis and partly to the use of immune-suppressing medications for treatment.
  • Digestive tract problems: Many people experience stomach and intestinal distress. Again, this is more often a side effect of medications used to treat rheumatoid arthritis.
  • Osteoporosis: Osteoporosis, or the loss of bone density, is more common in women with rheumatoid arthritis than in women in general. The hip is particularly affected. The risk for osteoporosis also appears to be higher than average in men with rheumatoid arthritis who are older than 60 years.
  • Lung disease: Certain conditions involving inflammation of the lungs seem to be more common in people with rheumatoid arthritis than in the general population. These include pleurisy and pleuritis, lung infections, lung nodules, and pulmonary fibrosis. However, a definite link between cigarette smoking and rheumatoid arthritis may at least partly account for this finding. Cigarette smoking, in any case, may increase the severity of the disease.
  • Heart disease: Rheumatoid arthritis can affect the blood vessels and may increase the risk for coronary heart disease.
  • Sjögren's syndrome: This is another autoimmune rheumatic disease, like rheumatoid arthritis. It causes extreme dryness of certain body tissues, especially the eyes and mouth. Dryness of the eyes is common in people with rheumatoid arthritis.
  • Felty's syndrome: This condition combines enlargement of the spleen with impairment of the immune system (low white blood cell count), leading to recurrent bacterial infections. This syndrome sometimes responds to DMARD therapy.
  • Lymphoma and other cancers: The risk for lymphoma, a cancer of the lymph nodes, is higher than normal in people with rheumatoid arthritis. This is thought to be a result of abnormalities in the immune system. The risk of lymphoma is higher in those patients with active inflammatory disease. Other cancers that may be more common in people with rheumatoid arthritis include prostate and lung cancers.
  • Fibromyalgia, a chronic pain syndrome, is more common in people with autoimmune diseases such as rheumatoid arthritis and lupus than in the general population.
  • Rheumatoid vasculitis: This is an autoimmune inflammation of the blood vessels that can occur in patients who have severe, active rheumatoid arthritis for many years. The symptoms of this are a very specific-looking rash or nonhealing ulcerations on the legs.
  • Macrophage activation syndrome: This is a life-threatening complication of rheumatoid arthritis. It is diagnosed by bone marrow testing and requires immediate treatment. Symptoms include persistent fever, weakness, drowsiness, and lethargy.

Overall, the rate of premature death is higher in people with rheumatoid arthritis than in the general population. The most common causes of premature death in people with rheumatoid arthritis are infection, vasculitis, and poor nutrition. Fortunately, the manifestations of severe, long-standing disease, such as nodules, vasculitis, and deforming are becoming less common with optimal treatments.

Medically Reviewed by a Doctor on 9/11/2017

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Rheumatoid Arthritis »

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown cause that primarily affects the peripheral joints in a symmetric pattern.

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