Acide Désoxyribonucléique, Acide Nucléique, Acides Nucléiques, ADN, ADN-ARN, ADN/ARN, ARN et ADN, ARN y ADN, DNA, Deoxynucleic Acid, Deoxyribonucleic Acid, Extrait Ribonucléique, Nuclei Acids, Nucleic, Nucleic Acid, Nucleic Acids, Nucleotides, Nucléotides, Purines, Pyrimidines, RNA, RNA-DNA, RNA/DNA, Ribonucleic Acid, Ribonucleic Extract.
RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) are chemical compounds that can be made by the body. They can also be made in a laboratory. RNA and DNA are used as medicine.
People take RNA/DNA combinations to improve memory and mental sharpness, treat or prevent Alzheimer's disease, treat depression, increase energy, tighten skin, increase sex drive, and counteract the effects of aging.
In the hospital, RNA is used in nutrition formulas that include omega-3 fatty acids and arginine. The combination is used for reducing the time needed for recovery after surgery, boosting the immune system's response, and improving outcomes for burn patients and intensive care patients.
How does it work?
RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) are chemicals called nucleotides that are made by the body. They appear to be essential under conditions of rapid growth such as intestinal development, liver surgery or injury, and also during challenges to the immune system.
Possibly Effective for...
- Shortening recovery from surgery or illness. Supplementing the diet of patients undergoing major surgery with RNA, L-arginine, and eicosapentaenoic acid might improve recovery. Giving this combination around the time of surgery appears to boost immune response, reduce infections, improve wound healing, and shorten recovery time.
Possibly Ineffective for...
- Burn injury recovery.
Insufficient Evidence to Rate Effectiveness for...
- Alzheimer's disease.
- Improving memory.
- Sagging skin.
- Decreased sex drive.
- Eczema, when given as a shot.
- Psoriasis, when given as a shot.
- Hives, when given as a shot.
- Shingles, when given as a shot.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
RNA appears to be safe for most people when taken along with omega-3 fatty acids and L-arginine or injected under the skin. Injections can cause itching, redness, and swelling at the injection site.
Infant formulas that contain RNA or DNA also seem to be safe for children.
There isn't enough information to know whether RNA/DNA combinations are safe to take by mouth.
Not enough is known about the safety of using RNA and DNA if you are breast-feeding. Stay on the safe side and avoid use.
The following dose has been studied in scientific research:
BY FEEDING TUBE:
- For improving surgical recovery: 30 mg/kg/day of RNA along with arginine and omega-3 fatty acids.
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Bower RH, Cerra FB, Bershadsky B, et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized clinical trial. Crit Care Med 1995;23:436-49. View abstract.
Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic and clinical outcome. Surgery 1992;112:56-67. View abstract.
Gianotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine, omega-3-fatty acid, and RNA-enriched enteral diet: effect on host response and nutritional status. JPEN J Parenter Enteral Nutr 1999;23:314-20. View abstract.
Kemen M, Senkal M, Homann HH, et al. Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet vs placebo in cancer patients: an immunologic evaluation of impact. Crit Care Med 1995;23:652-9. View abstract.
Li L. Erythematous skin reaction to subcutaneous injection of ribonucleic acid. Contact Dermatitis 1999;41:239.
Rudolph FB, Van Buren CT. The metabolic effects of enterally administered ribonucleic acids. Curr Opin Clin Nutr Metab Care 1998;1:527-30. View abstract.
Saffle JR, Wiebke G, Jennings K, et al. Randomized trial of immune-enhancing enteral nutrition in burn patients. J Trauma 1997;42:793-802. View abstract.
Schubert R, Hohlweg U, Renz D, Doefler W. On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission o the fetus. Mol Gen Genet 1998;259:569-76.
Senkal M, Kemen M, Homann HH, et al. Modulation of postoperative immune response by enteral nutrition with a diet enriched with arginine, RNA, and omega-3 fatty acids in patients with upper gastrointestinal cancer. Eur J Surg 1995;161:115-22. View abstract.
Tepaske R, Velthuis H, Oudemans-van Straaten HM, et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet 2001;358:696-701. View abstract.
Van Buren CT, Rudolph F. Dietary nucleotides: a conditional requirement. Nutrition 1997;13:470-2. View abstract.