Saccharomyces Boulardii

Other Name(s):

Brewer's Yeast (Hansen CBS 5926), Hansen CBS 5926, Levure de Boulangerie (Hansen CBS 5926), Probiotic, Probiotique, Saccharomyces, Saccharomyces boulardii, Saccharomyces Cerevisiae, S. Boulardii.


Saccharomyces boulardii is a yeast, which is a type of fungus. Saccharomyces boulardii was previously identified as a unique species of yeast, but is now believed to be a strain of Saccharomyces cerevisiae (baker's yeast). Saccharomyces boulardii is used as medicine.

Saccharomyces boulardii is used for treating and preventing diarrhea, including infectious types such as rotaviral diarrhea in children, diarrhea caused by gastrointestinal (GI) take-over (overgrowth) by “bad” bacteria in adults, traveler's diarrhea, and diarrhea associated with tube feedings. It is also used to prevent and treat diarrhea caused by the use of antibiotics.

Saccharomyces boulardii is also used for general digestion problems, irritable bowel syndrome (IBS), inflammatory bowel syndrome (IBD, Crohn's disease, ulcerative colitis), Lyme disease, a bowel disorder called relapsing Clostridium difficile colitis, and bacterial overgrowth in short bowel syndrome.

Some people use Saccharomyces boulardii for lactose intolerance, urinary tract infections (UTIs), vaginal yeast infections, high cholesterol levels, hives, fever blisters, canker sores, and teen-age acne.

How does it work?

Saccharomyces boulardii is called a "probiotic," a friendly organism that helps to fight off disease-causing organisms in the gut such as bacteria and yeast.

Uses & Effectiveness

Likely Effective for...

  • Diarrhea associated with antibiotics. Most research shows that taking Saccharomyces boulardii can prevent diarrhea caused by taking antibiotics.
  • Diarrhea. Most research shows that Saccharomyces boulardii can prevent diarrhea in people with feeding tubes. It also appears to help treat diarrhea in infants and children.

Possibly Effective for...

  • Acne. Some research suggests that taking a type of Saccharomyces boulardii (Perenterol, Cell Tech Phama) by mouth can improve the appearance of acne.
  • Diarrhea caused by the bacteria Clostridium difficile. Taking Saccharomyces boulardii by mouth along with the antibiotics vancomycin or metronidazole prevents the recurrence of diarrhea caused by the bacteria Clostridium difficile. However, it might not help treat first episodes of diarrhea caused by this type of bacteria.
  • Helicobacter pylori. Some evidence suggests that taking Saccharomyces boulardii reduces the side effects of treatment for ulcers caused by the bacteria Helicobacter pylori.
  • Diarrhea related to HIV. Taking Saccharomyces boulardii by mouth appears to reduce diarrhea related to HIV.
  • Traveler's diarrhea. Taking Saccharomyces boulardii by mouth appears to prevent traveler's diarrhea.

Insufficient Evidence to Rate Effectiveness for...

  • Amoeba infections (amebiasis). Early research shows that taking Saccharomyces boulardii by mouth along with antibiotics reduces diarrhea and stomach pain in people with amoeba infections.
  • Crohn's disease. Early research shows that Saccharomyces boulardii combined with mesalamine can help people with Crohn's disease stay in remission longer. Remission is a period of time during which symptoms of disease are controlled. Taking Saccharomyces boulardii also seems to reduce the number of bowel movements in people with Crohn's disease.
  • Cystic fibrosis. Early research shows that taking Saccharomyces boulardii by mouth does not seem to reduce yeast infections in the digestive tract of people with cystic fibrosis.
  • Irritable bowel syndrome (IBS). Early research suggests that taking Saccharomyces boulardii by mouth might improve bowel movements, stomach pain, bloating, and upset stomach in people with IBS.
  • Ulcerative colitis. Early research shows that adding Saccharomyces boulardii to standard mesalamine therapy can reduce symptoms in people with mild-to-moderate ulcerative colitis.
  • Urinary tract infections (UTIs).
  • Yeast infections.
  • High cholesterol.
  • Lyme disease.
  • Hives.
  • Fever blisters.
  • Canker sores.
  • Lactose intolerance.
  • Other conditions.
More evidence is needed to rate Saccharomyces boulardii for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


Pancreatitis is inflammation of an organ in the abdomen called the pancreas. See Answer

Side Effects

Saccharomyces boulardii is LIKELY SAFE for most adults when taken by mouth for up to 15 months. It can cause gas in some people. Rarely, it might cause fungal infections that can spread through the bloodstream to the entire body (fungemia).

Special Precautions & Warnings

Children. Saccharomyces boulardii is POSSIBLY SAFE for children when taken by mouth appropriately. However, diarrhea in children should be evaluated by a healthcare professional before using Saccharomyces boulardii.

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Saccharomyces boulardii if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Weakened immune system: There is some concern that critically ill people, people who have a weakened immune system, and people who are taking medicines that alter the immune system might have an increased risk for developing a yeast infection that spreads to the bloodstream and the rest of the body (fungemia) if they take Saccharomyces boulardii. Although Saccharomyces generally doesn't cause disease, there have been numerous cases of fungemia following its use, primarily in people with a weakened immune system.

Yeast allergy: People with yeast allergy can be allergic to products containing Saccharomyces boulardii, and are best advised to avoid these products.


Medications for fungal infections (Antifungals)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.

Saccharomyces boulardii is a fungus. Medications for fungal infections help reduce fungus in and on the body. Taking Saccharomyces boulardii with medications for fungal infections can reduce the effectiveness of Saccharomyces boulardii.

Some medications for fungal infection include fluconazole (Diflucan), terbinafine (Lamisil), itraconazole (Sporanox), and others.


The following doses have been studied in scientific research:


  • For diarrhea associated with the use of antibiotics: 250-500 mg of Saccharomyces boulardii two to four times a day.
  • For diarrhea caused by Clostridium difficile: 1 gram of Saccharomyces boulardii daily for 4 weeks along with antibiotic treatment.
  • For Crohn's disease:
    • 250 mg of Saccharomyces boulardii three times daily has been used for up to 9 weeks.
    • 1 gram of Saccharomyces boulardii daily in combination with usual treatment has also been used.
  • For ulcerative colitis: 205 mg of Saccharomyces boulardii three times daily.
  • For treatment of infections due to the ulcer-causing Helicobacter pylori bacterium: a dose of 5 billion colony-forming units (CFUs) of Saccharomyces boulardii daily in addition to usual treatment.


Buts, J. P. [Lyophilized Saccharomyces boulardii: example of a probiotic medicine]. Rev.Gastroenterol.Peru 2005;25(2):176-188. View abstract.

Enache-Angoulvant, A. and Hennequin, C. Invasive Saccharomyces infection: a comprehensive review. Clin.Infect.Dis. 12-1-2005;41(11):1559-1568. View abstract.

Kotowska, M., Albrecht, P., and Szajewska, H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment.Pharmacol.Ther. 3-1-2005;21(5):583-590. View abstract.

Mansour-Ghanaei, F., Dehbashi, N., Yazdanparast, K., and Shafaghi, A. Efficacy of saccharomyces boulardii with antibiotics in acute amoebiasis. World J Gastroenterol. 2003;9(8):1832-1833. View abstract.

Adam J, Barret C, Barret-Bellet A, and et al. Essais cliniques controles en double insu de l'Ultra-Levure Lyophilisee. Etude multicentrique par 25 medecins de 388 cas. Gaz Med Fr 1977;84:2072-2078.

Akil, I., Yilmaz, O., Kurutepe, S., Degerli, K., and Kavukcu, S. Influence of oral intake of Saccharomyces boulardii on Escherichia coli in enteric flora. Pediatr Nephrol. 2006;21(6):807-810. View abstract.

Akisu, M., Baka, M., Yalaz, M., Huseyinov, A., and Kultursay, N. Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. Eur.J Pediatr.Surg 2003;13(5):319-323. View abstract.

Akyol, S., Mas, M. R., Comert, B., Ateskan, U., Yasar, M., Aydogan, H., Deveci, S., Akay, C., Mas, N., Yener, N., and Kocar, I. H. The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis. Pancreas 2003;26(4):363-367. View abstract.

Aldemir, M., Kokoglu, O. F., Geyik, M. F., and Buyukbayram, H. Effects of octreotide acetate and Saccharomyces boulardii on bacterial translocation in an experimental intestinal loop obstruction model of rats. Tohoku J Exp.Med 2002;198(1):1-9. View abstract.

Algin, C., Sahin, A., Kiraz, N., Sahinturk, V., and Ihtiyar, E. Effectiveness of bombesin and Saccharomyces boulardii against the translocation of Candida albicans in the digestive tract in immunosuppressed rats. Surg Today 2005;35(10):869-873. View abstract.

AS, B. and LP, S. Effect of probiotic containing Saccharomyces boulardii on experimental ochratoxicosis in broilers: hematobiochemical studies. J Vet.Sci 2004;5(4):359-367. View abstract.

Bahgat, M., Maghraby, A. S., Ab Del-Fatah, O. M., and Elshafei, A. M. Immunization of mice with crude extract of Saccharomyces boulardii yeast induces cross-reactive immune responses with antigenic preparations from different developmental stages of the Schistosoma mansoni and reduces the parasite worm burden. J Egypt.Soc Parasitol. 2005;35(2):563-580. View abstract.

Bassetti S, Frei R, Zimmerli W. Fungemia with Saccharomyces cerevisiae after treatment with Saccharomyces boulardii. Am J Med 1998;105:71-2. View abstract.

Baum, B., Liebler-Tenorio, E. M., Enss, M. L., Pohlenz, J. F., and Breves, G. Saccharomyces boulardii and bacillus cereus var. Toyoi influence the morphology and the mucins of the intestine of pigs. Z Gastroenterol. 2002;40(5):277-284. View abstract.

Blehaut, H., Massot, J., Elmer, G. W., and Levy, R. H. Disposition kinetics of Saccharomyces boulardii in man and rat. Biopharm.Drug Dispos. 1989;10(4):353-364. View abstract.

Bleichner G and Blehaut H. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A multicenter, randomized, double-blind placebo-controlled trial [abstract]. Clin Nutr 1994;13 Suppl 1:10.

Bleichner G, Blehaut H, Mentec H, et al. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. Intensive Care Med 1997;23:517-23. View abstract.

Boddy, A. V., Elmer, G. W., McFarland, L. V., and Levy, R. H. Influence of antibiotics on the recovery and kinetics of Saccharomyces boulardii in rats. Pharm.Res 1991;8(6):796-800. View abstract.

Born, P., Lersch, C., Zimmerhackl, B., and Classen, M. [The Saccharomyces boulardii therapy of HIV-associated diarrhea]. Dtsch Med Wochenschr 5-21-1993;118(20):765. View abstract.

Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. View abstract.

Broussard, E. K. and Surawicz, C. M. Probiotics and prebiotics in clinical practice. Nutr Clin Care 2004;7(3):104-113. View abstract.

Burkhardt, O., Kohnlein, T., Pletz, M., and Welte, T. Saccharomyces boulardii induced sepsis: successful therapy with voriconazole after treatment failure with fluconazole. Scand.J Infect.Dis. 2005;37(1):69-72. View abstract.

Buts JP, Corthier G, Delmee M. Saccharomyces boulardii for Clostridium difficile-associated enteropathies in infants. J Pediatr Gastroenterol Nutr 1993;16:419-25. View abstract.

Buts, J. P., Bernasconi, P., Vaerman, J. P., and Dive, C. Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with View abstract.

Buts, J. P., Bernasconi, P., Van Craynest, M. P., Maldague, P., and De Meyer, R. Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii. Pediatr.Res 1986;20(2):192-196. View abstract.

Buts, J. P., De Keyser, N., Stilmant, C., Sokal, E., and Marandi, S. Saccharomyces boulardii enhances N-terminal peptide hydrolysis in suckling rat small intestine by endoluminal release of a zinc-binding metalloprotease. Pediatr.Res 2002;51(4):528-534. View abstract.

Can M, Besirbellioglu BA, Avci IY, et al. Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: A prospective study. Med Sci Monit 2006;12:PI19-22. View abstract.

Cartwright-Shamoon, J., Dickson, G. R., Dodge, J., and Carr, K. E. Morphological aspects of particle translocation in vivo following ingestion of the yeast Saccharomyces boulardii. J Drug Target 1995;3(1):61-63. View abstract.

Cartwright-Shamoon, J., Dickson, G. R., Dodge, J., and Carr, K. E. Uptake of yeast (Saccharomyces boulardii) in normal and rotavirus treated intestine. Gut 1996;39(2):204-209. View abstract.

Castagliuolo I, Riegler MF, Valenick L, et al. Saccharomyces boulardii protease inhibits the effects of clostridium difficile toxins A and B in human colonic mucosa. Infection and Immun 1999;67:302-7. View abstract.

Castagliuolo, I., LaMont, J. T., Nikulasson, S. T., and Pothoulakis, C. Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect.Immun. 1996;64(12):5225-5232. View abstract.

Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. View abstract.

Cetina-Sauri G and Basto GS. Evaluacion terapeutica de Saccharomyces boulardii en ninos con diarrea aguda. Tribuna Med 1989;56:111-115.

Chapoy, P. [Treatment of acute infantile diarrhea: controlled trial of Saccharomyces boulardii]. Ann Pediatr.(Paris) 1985;32(6):561-563. View abstract.

Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. View abstract.

Chouraqui JP, Dietsch J, Musial C, and et al. Saccharomyces boulardii (SB) in the management of toddler diarrhea: a double-blind-placebo controlled study [abstract]. J Pediatr Gastroenterol Nutr 1995;20(4):463.

Cimolai, N., Gill, M. J., and Church, D. Saccharomyces cerevisiae fungemia: case report and review of the literature. Diagn.Microbiol.Infect.Dis 1987;8(2):113-117. View abstract.

Costalos, C., Skouteri, V., Gounaris, A., Sevastiadou, S., Triandafilidou, A., Ekonomidou, C., Kontaxaki, F., and Petrochilou, V. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum.Dev. 2003;74(2):89-96. View abstract.

Cremonini F, Di Caro S, Covino M, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002;97:2744-9. View abstract.

Cremonini, F., Di Caro, S., Santarelli, L., Gabrielli, M., Candelli, M., Nista, E. C., Lupascu, A., Gasbarrini, G., and Gasbarrini, A. Probiotics in antibiotic-associated diarrhoea. Dig.Liver Dis. 2002;34 Suppl 2:S78-S80. View abstract.

Czerucka D, Roux I, Rampal P. Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3',5'-cyclic monophosphate induction in intestinal cells. Gastroenterol 1994;106:65-72. View abstract.

Czerucka, D., Nano, J. L., Bernasconi, P., and Rampal, P. [Response to cholera toxin of 2 epithelial intestinal cell lines. Effect of Saccharomyces boulardii]. Gastroenterol.Clin.Biol 1989;13(4):383-387. View abstract.

D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002;324:1361. View abstract.

Dahan, S., Dalmasso, G., Imbert, V., Peyron, J. F., Rampal, P., and Czerucka, D. Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infect.Immun. 2003;71(2):766-773. View abstract.

Dalmasso, G., Loubat, A., Dahan, S., Calle, G., Rampal, P., and Czerucka, D. Saccharomyces boulardii prevents TNF-alpha-induced apoptosis in EHEC-infected T84 cells. Res Microbiol 2006;157(5):456-465. View abstract.

De, Preter, V, Vanhoutte, T., Huys, G., Swings, J., Rutgeerts, P., and Verbeke, K. Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects. Aliment.Pharmacol Ther 4-1-2006;23(7):963-974. View abstract.

Desrochers, A. M., Dolente, B. A., Roy, M. F., Boston, R., and Carlisle, S. Efficacy of Saccharomyces boulardii for treatment of horses with acute enterocolitis. J Am Vet.Med Assoc 9-15-2005;227(6):954-959. View abstract.

Ducluzeau, R. and Bensaada, M. [Comparative effect of a single or continuous administration of "Saccharomyces boulardii" on the establishment of various strains of "candida" in the digestive tract of gnotobiotic mice]. Ann Microbiol.(Paris) 1982;133(3):491-501. View abstract.

Duman, D. G., Bor, S., Ozutemiz, O., Sahin, T., Oguz, D., Istan, F., Vural, T., Sandkci, M., Isksal, F., Simsek, I., Soyturk, M., Arslan, S., Sivri, B., Soykan, I., Temizkan, A., Bessk, F., Kaymakoglu, S., and Kalayc, C. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol.Hepatol. 2005;17(12):1357-1361. View abstract.

ElHennawy, A. A., Wong, C. T., and Kocoshis, S. A. Failure of Saccharomyces boulardii to hydrolyse bile acids in vitro. Microbios 1994;80(322):23-29. View abstract.

Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8. View abstract.

Elmer GW, McFarland LV. Comment on the lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhea in elderly patients. J Infect 1998;37:307-8. View abstract.

Elmer GW, Moyer KA, Vega R, and et al. Evaluation of Saccharomyces boulardii for patients with HIV-related chronic diarrhoea and in healthy volunteers receiving antifungals. Microecology Ther 1995;25:23-31.

Elmer, G. W. and McFarland, L. V. Suppression by Saccharomyces boulardii of toxigenic Clostridium difficile overgrowth after vancomycin treatment in hamsters. Antimicrob.Agents Chemother. 1987;31(1):129-131. View abstract.

Erdeve, O., Tiras, U., and Dallar, Y. The probiotic effect of Saccharomyces boulardii in a pediatric age group. J Trop.Pediatr. 2004;50(4):234-236. View abstract.

Fietto, J. L., Araujo, R. S., Valadao, F. N., Fietto, L. G., Brandao, R. L., Neves, M. J., Gomes, F. C., Nicoli, J. R., and Castro, I. M. Molecular and physiological comparisons between Saccharomyces cerevisiae and Saccharomyces boulardii. Can.J Microbiol. 2004;50(8):615-621. View abstract.

Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3. View abstract.

Gaon, D., Garcia, H., Winter, L., Rodriguez, N., Quintas, R., Gonzalez, S. N., and Oliver, G. Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children. Medicina (B Aires) 2003;63(4):293-298. View abstract.

Gedek, B. R. Adherence of Escherichia coli serogroup O 157 and the Salmonella typhimurium mutant DT 104 to the surface of Saccharomyces boulardii. Mycoses 1999;42(4):261-264. View abstract.

Geyik, M. F., Aldemir, M., Hosoglu, S., Ayaz, C., Satilmis, S., Buyukbayram, H., and Kokoglu, O. F. The effects of Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice. Ann R.Coll Surg Engl. 2006;88(2):176-180. View abstract.

Girard, P., Pansart, Y., and Gillardin, J. M. Inducible nitric oxide synthase involvement in the mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhoea in rats. Nitric.Oxide. 7-19-2005; View abstract.

Girard, P., Pansart, Y., Coppe, M. C., and Gillardin, J. M. Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon. Dig.Dis.Sci 2005;50(11):2183-2190. View abstract.

Girard, P., Pansart, Y., Lorette, I., and Gillardin, J. M. Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats. Dig.Dis.Sci 2003;48(4):770-774. View abstract.

Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 2003;15:697-8. View abstract.

Guslandi M, Mezzi G, Sorghi M, Testoni PA. Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci 2000;45:1462-4. View abstract.

Hennequin C, Kauffmann-Lacroix C, Jobert A, et al. Possible role of catheters in Saccharomyces boulardii fungemia. Eur J Clin Microbiol Infect Dis 2000;19:16-20. View abstract.

Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9. View abstract.

Henry, S., D'Hondt, L., Andre, M., Holemans, X., and Canon, J. L. Saccharomyces cerevisiae fungemia in a head and neck cancer patient: a case report and review of the literature. Acta Clin Belg. 2004;59(4):220-222. View abstract.

Herbrecht, R. and Nivoix, Y. Saccharomyces cerevisiae fungemia: an adverse effect of Saccharomyces boulardii probiotic administration. Clin.Infect.Dis. 6-1-2005;40(11):1635-1637. View abstract.

Herek, O., Kara, I. G., and Kaleli, I. Effects of antibiotics and Saccharomyces boulardii on bacterial translocation in burn injury. Surg Today 2004;34(3):256-260. View abstract.

Joossens, S., Suenaert, P., Noman, M., Vermeire, S., and Rutgeerts, P. Saccharomyces boulardii in Crohn's disease: effect on anti-Saccharomyces cerevisiae antibodies and intestinal permeability. Inflamm.Bowel.Dis 2005;11(9):863-864. View abstract.

Kamm, K., Hoppe, S., Breves, G., Schroder, B., and Schemann, M. Effects of the probiotic yeast Saccharomyces boulardii on the neurochemistry of myenteric neurones in pig jejunum. Neurogastroenterol.Motil. 2004;16(1):53-60. View abstract.

Kimmey, M. B., Elmer, G. W., Surawicz, C. M., and McFarland, L. V. Prevention of further recurrences of Clostridium difficile colitis with Saccharomyces boulardii. Dig.Dis Sci 1990;35(7):897-901. View abstract.

Kirchhelle, A., Fruhwein, N., and Toburen, D. [Treatment of persistent diarrhea with S. boulardii in returning travelers. Results of a prospective study]. Fortschr Med 4-20-1996;114(11):136-140. View abstract.

Kirillov, D. A., Perunova, N. B., Chelpachenko, O. E., Elagina, N. N., Valyshev, A. V., and Bukharin, O. V. [Modifying action of Saccharomyces boulardii on the biological properties of enterobacteria]. Zh.Mikrobiol.Epidemiol.Immunobiol. 2002;(4):57-59. View abstract.

Klein, S. M., Elmer, G. W., McFarland, L. V., Surawicz, C. M., and Levy, R. H. Recovery and elimination of the biotherapeutic agent, Saccharomyces boulardii, in healthy human volunteers. Pharm.Res 1993;10(11):1615-1619. View abstract.

Kollaritsch, H., Holst, H., Grobara, P., and Wiedermann, G. [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr.Med 3-30-1993;111(9):152-156. View abstract.

Krammer M, Karbach U. Antidiarrheal action of the yeast Saccharomyces boulardii in the rat small and large intestine by stimulating chloride absorption. Z Gastroenterol 1993;31:73-7.

Kurugol, Z. and Koturoglu, G. Effects of Saccharomyces boulardii in children with acute diarrhoea. Acta Paediatr. 2005;94(1):44-47. View abstract.

Lee, S. K., Kim, H. J., Chi, S. G., Jang, J. Y., Nam, K. D., Kim, N. H., Joo, K. R., Dong, S. H., Kim, B. H., Chang, Y. W., Lee, J. I., and Chang, R. [Saccharomyces boulardii activates expression of peroxisome proliferator-activated receptor-gamma in HT-29 cells]. Korean J Gastroenterol. 2005;45(5):328-334. View abstract.

Lestin, F., Pertschy, A., and Rimek, D. [Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities]. Dtsch.Med Wochenschr. 11-28-2003;128(48):2531-2533. View abstract.

Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. View abstract.

Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhea in elderly patients. J Infect 1998;36:171-4. View abstract.

Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. View abstract.

Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. View abstract.

Maupas JL, Champemont P, and Delforge M. [Treatment of irritable bowel syndrome with Saccharomyces boulardii - a double-blind, placebo controlled study]. M├ędicine et Chirurgie Digestives 1983;12(1):77-79.

McCullough MJ, Clemons KV, McCusker JH, Stevens DA. Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.). J Clin Microbiol 1998;36:2613-7. View abstract.

McFarland LV, Surawicz C, Greenberg R, and et al. Saccharomyces boulardii and high dose vancomycin treats recurrent Clostridium difficile disease [abstract]. Am J Gastroenterol 1998;93(9):1694.

McFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994;271:1913-8. View abstract.

McFarland LV, Surawicz CM, Greenberg RN, et al. Prevention of beta-lactam associated diarrhea by Saccharomyces boulardii compared with placebo. Am J Gastroenterol 1995;90:439-48. View abstract.

McFarland LV, SurawiczCM, Elmer GW, and et al. Multivariate analysis of the clinical efficacy of a biotherapeutic agent, Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea [abstract]. Am J Epidemiol 1993;138:649.

McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006;101:812-22. View abstract.

McFarland LV. Saccharomyces boulardii is not Saccharomyces cerevisiae. Clin Infect Dis 1996;22:200-1. View abstract.

Mitterdorfer, G., Mayer, H. K., Kneifel, W., and Viernstein, H. Clustering of Saccharomyces boulardii strains within the species S. cerevisiae using molecular typing techniques. J Appl.Microbiol 2002;93(4):521-530. View abstract.

Mitterdorfer, G., Mayer, H. K., Kneifel, W., and Viernstein, H. Protein fingerprinting of Saccharomyces isolates with therapeutic relevance using one- and two-dimensional electrophoresis. Proteomics. 2002;2(11):1532-1538. View abstract.

Muller J, Remus N, Harms KH. Mycoserological study of the treatment of paediatric cystic fibrosis patients with Saccharomyces boulardii (Saccharomyces cerevisiae Hansen CBS 5926). Mycoses 1995;38:119-23. View abstract.

Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. View abstract.

Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930. View abstract.

Oeztuerk, H., Schroeder, B., Beyerbach, M., and Breves, G. Influence of living and autoclaved yeasts of Saccharomyces boulardii on in vitro ruminal microbial metabolism. J Dairy Sci 2005;88(7):2594-2600. View abstract.

Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34. View abstract.

Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. View abstract.

Posteraro, B., Sanguinetti, M., Romano, L., Torelli, R., Novarese, L., and Fadda, G. Molecular tools for differentiating probiotic and clinical strains of Saccharomyces cerevisiae. Int J Food Microbiol 9-15-2005;103(3):295-304. View abstract.

Potts L, Lewis SJ, and Barry R. Randomised double blind placebo controlled study of the ability of Saccharomyces boulardii to prevent antibiotic related diarrhoea [abstract]. Gut 1996;38 (suppl 1):A61.

Rijnders, B. J., Van Wijngaerden, E., Verwaest, C., and Peetermans, W. E. Saccharomyces fungemia complicating Saccharomyces boulardii treatment in a non-immunocompromised host. Intensive Care Med 2000;26(6):825. View abstract.

Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41-43. View abstract.

Rodrigues, A. C., Cara, D. C., Fretez, S. H., Cunha, F. Q., Vieira, E. C., Nicoli, J. R., and Vieira, L. Q. Saccharomyces boulardii stimulates sIgA production and the phagocytic system of gnotobiotic mice. J Appl.Microbiol. 2000;89(3):404-414. View abstract.

Saavedra J. Probiotics and infectious diarrhea. Am J Gastroenterol 2000;95:S16-8. View abstract.

Saint-Marc T, Blehaut H, Musial C, and et al. [AIDS-related diarrhea: a double-blind trial of Saccharomyces boulardii]. Semaine Des Hopitaux 1995;71(23-24):735-741.

Saint-Marc T, Rossello-Prats L, and Touraine JL. [Effectiveness of Saccharomyces boulardii in the management of AIDS diarrhea]. Ann Med Interne (Paris) 1991;142(1):64-65.

Saint-Marc, T., Rossello-Prats, L., and Touraine, J. L. [Efficacy of Saccharomyces boulardii in the treatment of diarrhea in AIDS]. Ann Med Interne (Paris) 1991;142(1):64-65. View abstract.

Scarpignato C, Rampal P. Prevention and treatment of traveler's diarrhea: A clinical pharmacological approach. Chemotherapy 1995;41:48-81. View abstract.

Schneider, S. M., Girard-Pipau, F., Filippi, J., Hebuterne, X., Moyse, D., Hinojosa, G. C., Pompei, A., and Rampal, P. Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition. World J Gastroenterol. 10-21-2005;11(39):6165-6169. View abstract.

Schroeder, B., Winckler, C., Failing, K., and Breves, G. Studies on the time course of the effects of the probiotic yeast Saccharomyces boulardii on electrolyte transport in pig jejunum. Dig.Dis.Sci 2004;49(7-8):1311-1317. View abstract.

Shanahan, F. Probiotics in inflamatory bowel disease. Gut 2001;48(5):609. View abstract.

Sougioultzis, S., Simeonidis, S., Bhaskar, K. R., Chen, X., Anton, P. M., Keates, S., Pothoulakis, C., and Kelly, C. P. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys.Res Commun. 4-28-2006;343(1):69-76. View abstract.

Surawicz CM, Elmer GW, Speelman P, et al. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989;96:981-8. View abstract.

Surawicz CM, McFarland LV, Elmer G, et al. Treatment of recurrent clostridium difficile colitis with vancomycin and Saccharomyces boulardii. Am J Gastroenterol 1989;84:1285-7. View abstract.

Surawicz, C. M. Treatment of recurrent Clostridium difficile-associated disease. Nat Clin Pract.Gastroenterol.Hepatol. 2004;1(1):32-38. View abstract.

Surawicz, C. M., McFarland, L. V., Greenberg, R. N., Rubin, M., Fekety, R., Mulligan, M. E., Garcia, R. J., Brandmarker, S., Bowen, K., Borjal, D., and Elmer, G. W. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin.Infect.Dis. 2000;31(4):1012-1017. View abstract.

Szajewska H, Mrukowicz J. Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2005;22:365-72. View abstract.

Tasteyre, A., Barc, M. C., Karjalainen, T., Bourlioux, P., and Collignon, A. Inhibition of in vitro cell adherence of Clostridium difficile by Saccharomyces boulardii. Microb.Pathog. 2002;32(5):219-225. View abstract.

Tempe, J. D., Steidel, A. L., Blehaut, H., Hasselmann, M., Lutun, P., and Maurier, F. [Prevention of diarrhea administering Saccharomyces boulardii during continuous enteral feeding]. Sem.Hop. 5-5-1983;59(18):1409-1412. View abstract.

Viggiano, M., Badetti, C., Bernini, V., Garabedian, M., and Manelli, J. C. [Saccharomyces boulardii fungemia in a patient with severe burns]. Ann Fr.Anesth.Reanim. 1995;14(4):356-358. View abstract.

Weber G, Adamczyk A, Freytag S. [Treatment of acne with a yeast preparation]. Fortschr Med 1989;107:563-6. View abstract.

Zunic, P., Lacotte, J., Pegoix, M., Buteux, G., Leroy, G., Mosquet, B., and Moulin, M. [Saccharomyces boulardii fungemia. Apropos of a case]. Therapie 1991;46(6):498-499. View abstract.

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