In the final episode of The Sopranos, which aired in 2007, fans saw the mobster’s daughter, Meadow, run across the street to meet her family for dinner. That, says Jamie-Lynn Sigler, who played the character throughout the show’s six-season run, was the last time she ever ran. Sigler was diagnosed with MS in 2001 but stayed quiet about it for years because she feared it would affect her career. In early 2016, she came forward with it. She told People magazine, "It's part of me, but it's not who I am." She takes medication twice a day and says her MS is manageable.