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Symptoms and Signs of Brown Recluse Spider Bite

Doctor's Notes on Brown Recluse Spider Bite

Brown recluse spiders are small, yellow to tan, non-hairy spiders with a characteristic violin pattern on the back of the cephalothorax (the body part where the legs attach). These spiders are not aggressive and bite only when threatened, but their venom is extremely poisonous and causes tissue death in the area of the bite.

Symptoms of a brown recluse spider bite include severe pain at the site and redness of the area. Sometimes there is a purple or blue area around the bite that is surrounded by a whitish ring and a large outer ring in a bull's eye pattern. Eventually, a blister forms at the site if the bite and sloughs off to leave a deep ulcer that may turn black. Associated symptoms can include fever, nausea, vomiting, headache, and muscle pain.

Medical Author:
Medically Reviewed on 5/2/2019

Brown Recluse Spider Bite Symptoms

Brown recluse spider bites often go unnoticed initially because they are usually painless bites. Occasionally, some minor burning that feels like a bee sting is noticed at the time of the bite and a small white blister develops at the site of the bite. Symptoms usually develop two to eight hours after a bite. Keep in mind that most bites cause little tissue destruction.

Victims may experience these symptoms:

Initially the bite site is mildly red and upon close inspection may reveal fang marks. Most commonly, the bite site will become firm and heal with little scaring over the next few days or weeks. Occasionally, the local reaction will be more severe with erythema and blistering, sometimes leading to a blue discoloration, and ultimately leading to a necrotic lesion and scarring. Signs that may be present include:

  • blistering (common),
  • necrosis (death) of skin and subcutaneous fat (less common), and
  • severe destructive necrotic lesions with deep wide borders (rare).

Brown Recluse Spider Bite Causes

The brown recluse venom is extremely poisonous, even more potent than that of a rattlesnake. Yet recluse venom causes less disease than a rattlesnake bite because of the small quantities injected into its victims. The venom of the brown recluse is toxic to cells and tissues.

  • This venom is a collection of enzymes. One of the specific enzymes, once released into the victim's skin, causes destruction of local cell membranes, which disrupts the integrity of tissues leading to local breakdown of skin, fat, and blood vessels. This process leads to eventual tissue death (necrosis) in areas immediately surrounding the bite site.
  • The venom also induces in its victim an immune response. The victim's immune system releases inflammatory agents-histamines, cytokines, and interleukins-that recruit signal specific disease-fighting white blood cells to the area of injury. In severe cases, however, these same inflammatory agents can themselves cause injury. These secondary effects of the venom, although extremely rare, can produce these more significant side effects of the spider bite:

Spider Bites How Dangerous Are They? Slideshow

Spider Bites How Dangerous Are They? Slideshow

When you think of spiders, what words come to mind? Creepy? Venomous? Deadly? Spiders are hunters, and they often use their fangs to take down their prey. But no spider in the world is large enough to hunt humans for food. In practically every case, a spider would prefer avoiding you over biting you.

They may look scary, but spiders actually help people. They kill a lot of tiny pests that infest homes. Fleas and mosquitos are more harmful to humans, and they're some spiders' favorite foods. So when you think of spiders, perhaps the words that should come to mind are "mostly harmless," and "surprisingly helpful."

There are roughly 40,000 different spider species around the world. Only about a dozen can harm humans, though. Even the spiders that are potentially harmful are unlikely to bite unless they think their lives are in danger. But if you do get bitten by a venomous spider, you will want to prepare yourself.


Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.