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Survival and Cause-Specific Mortality in Ulcerative Colitis

Reviewed on 9/11/2020

What Is Ulcerative Colitis?

Most people with ulcerative colitis live a normal lifespan when the disease is properly managed. For the small number for whom ulcerative colitis is fatal, the main causes include secondary cancers and autoimmune problems.

Ulcerative colitis is a chronic condition in which the large intestine (colon) becomes inflamed with sores (ulcers), resulting in diarrhea and bleeding. It typically affects the lower part of the colon and the rectum, but can affect the entire colon. 

Ulcerative colitis is related to Crohn's disease, another inflammatory condition of the intestines. While ulcerative colitis only affects the colon, Crohn's disease can affect any portion of the gastrointestinal tract from the mouth to the anus, including the bowels. Both ulcerative colitis and Crohn's disease are referred to as inflammatory bowel disease (IBD).

What Are Symptoms of Ulcerative Colitis?

Symptoms of ulcerative colitis include:

Patients with ulcerative colitis usually experience periods of relapse when inflammation and symptoms worsen, followed by periods of remission, lasting months to years when symptoms subside. 

What Causes Ulcerative Colitis?

The cause of ulcerative colitis is unknown, but the condition is believed to involve an abnormal activation of the immune system in the intestines, which causes chronic inflammation and ulceration in portions of the large intestine. 

This susceptibility to abnormal activation of the immune system is genetically inherited. Having a first-degree relative (brother, sister, child, and/or parent) who has ulcerative colitis is a risk factor for developing ulcerative colitis.

How Is Ulcerative Colitis Diagnosed?

Ulcerative colitis is diagnosed with a physical exam and patient history. The following tests may be performed: 

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What Is the Treatment for Ulcerative Colitis?

Ulcerative colitis is usually treated with medications. Medications do not cure ulcerative colitis. They are used to induce or maintain remissions and improve quality of life. Surgery is used as a last-resort for patients who have severe inflammation and life-threatening complications. 

Medications used to treat ulcerative colitis include:

Surgery for ulcerative colitis is a last-resort for severe cases and usually involves removing the entire colon and the rectum. Removal of the colon and rectum is the only permanent cure for ulcerative colitis. 

What Are Complications of Ulcerative Colitis?

Complications of ulcerative colitis include: 

What Is the Life Expectancy for Ulcerative Colitis?

Most people with ulcerative colitis live a normal lifespan when the disease is properly managed. 

For the small number for whom ulcerative colitis is fatal, the main causes include: 

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Reviewed on 9/11/2020
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