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Understanding Antidepressant Medications (cont.)

Trazodone (Desyrel)

  • Trazodone (Desyrel) may alter the blood levels and/or risk of toxicity of the following drugs:
    • Alcohol or other drugs that depress the central nervous system such as drugs taken for insomnia
    • clonidine (Catapres) (enhances blood pressure lowering effect)
    • digoxin (Lanoxin)
    • MAOIs
    • phenytoin or fosphenytoin (Dilantin, Cerebyx)
    • warfarin (Coumadin)
  • The following drugs may increase trazodone blood levels or toxicity:
    • Antifungal agents such as itraconazole (Sporanox) or ketoconazole (Nizoral)
    • carbamazepine (Tegretol)
    • Phenothiazines such as thioridazine (Mellaril)
    • ritonavir (Norvir)
    • SSRIs, sibutramine (Meridia), sumatriptan (Imitrex), trazodone (Desyrel), venlafaxine (Effexor), and St. John's wort (These medications may increase the risk for serotonin syndrome - symptoms include hypertension, fever, muscle tremor, or confusion.)
    • Drugs that may cause abnormal heart rhythms (check with the doctor or pharmacist)
Medically Reviewed by a Doctor on 12/10/2015
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