Font Size

Understanding Antidepressant Medications (cont.)

TCAs Drug or Food Interactions, Side Effects

Tell the doctor what medications are currently being taken because many medicines interact with TCAs. Do not take any nonprescription or herbal medications without first consulting the doctor or pharmacist. The following are examples of interactions, but they do not represent a complete list.

  • TCAs may increase the blood levels and/or risk of toxicity of the following medications:
    • MAOIs (These may cause serious and sometimes fatal reactions; some TCAs have been used safely with MAOIs, but the dose of TCAs must be increased very slowly and the person must strictly adhere to MAOI dietary restrictions.)
    • Sympathomimetics such as pseudoephedrine (Sudafed)
  • The following substances may increase the toxicity of TCAs:
  • Other interactions include the following:

Side Effects: This is NOT a complete list of possible side effects reported with TCAs. A doctor, health care provider, or pharmacist can discuss a more complete list of side effects.

  • Confusion, agitation, or hallucinations (Contact a doctor immediately if these occur.)
  • Severe diarrhea, fever, sweating, muscle stiffness, or tremors (These may be symptoms of neuroleptic malignant syndrome. Contact a doctor immediately.)
  • Rapid or abnormal heartbeat or fainting (Contact a doctor immediately if these occur.)
  • Changes in sexual interest or ability
  • Manic episodes in persons with bipolar disorder (If not combined with a mood-stabilizing medication, SSRIs may induce manic episodes in individuals with bipolar disorder [manic depression].)
  • Drowsiness (Caution is advised when operating machinery, driving, or performing other tasks that require alertness.)
  • Photosensitivity (increased risk of sunburn) (Use protective clothing, such as long sleeves and hats, and sunscreen to decrease the risk of sunburn.)
  • Rash
  • Nausea
  • Dry mouth
  • Urine retention
  • Blurred vision
  • Constipation
  • Lightheadedness when standing up from a sitting or lying position (Stand up gradually from lying down or sitting positions.)
  • Seizures (TCAs lower the threshold for seizures, that is, seizures may occur more easily in the person taking TCAs. Caution is advised for individuals prone to seizures or those who have a history of seizures.)
Medical Author:
Pharmacy Editor:

Must Read Articles Related to Understanding Antidepressant Medications

Insomnia Insomnia affects most people at some point in their lifetime. learn more >>
Panic Attacks
Panic Attacks Panic attacks are episodes of extreme learn more >>

Read What Your Physician is Reading on Medscape

Toxicity, Antidepressant »

Tricyclic antidepressants (TCAs) were one of the most important causes of mortality resulting from poisoning until 1993 and continue to be responsible for more deaths per prescription than all the other antidepressants put together.

Read More on Medscape Reference »

Medical Dictionary