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Understanding Asthma Medications (cont.)

Oral and Intravenous Corticosteroids for Asthma: Use, Side Effects, and Interactions

Methylprednisolone (Medrol, Solu-Medrol), prednisone (Deltasone, Orasone), and prednisolone (Pediapred) may need to be prescribed when inhaled medications fail to control asthma. Examples of such situations include after an acute asthma attack or when a respiratory infection or allergy aggravates asthma symptoms.

How corticosteroids work

Corticosteroids decrease the inflammation within the airway passages that contributes to asthma symptoms and acute attacks.

Who should not use these medications

  • Individuals who are allergic to corticosteroids should not use these drugs.
  • Individuals with systemic fungal infections or active tuberculosis should not use these drugs without medical supervision.


  • Dosage varies depending on the situation for which corticosteroids are being used.
  • Corticosteroids may be given as an intravenous (IV) injection for an acute asthma attack in the emergency room.
  • The frequency of initial oral use may be as often as three to four times per day for one to two days following an acute asthma attack. This large dose can be administered for several days. When corticosteroids are taken regularly, they should be taken once daily upon awakening (usually in the morning) to coincide with your body's normal biological rhythm. The smallest possible dose should be given to avoid long-term side effects. Some individuals can control their asthma symptoms with every-other-day dosing. When taking steroids chronically, they should not be abruptly discontinued.
  • Your doctor may try other asthma control medications to avoid long-term use of oral corticosteroids.
  • Take these drugs with food or milk to avoid stomach upset.

Drug or food interactions

Use caution with other drugs that suppress the immune system, such as cyclosporine (Sandimmune, Neoral). Phenobarbital (Luminol), phenytoin (Dilantin), or rifampin (Rifadin) may decrease the effectiveness of corticosteroids. Some drugs, such as ketoconazole (Nizoral) or erythromycin (E-Mycin, E.E.S.), may increase blood levels and toxicity of corticosteroids. An increased risk of stomach bleeding (bleeding ulcer) may occur when taken with high-dose aspirin or with blood thinners such as warfarin (Coumadin). Corticosteroids tend to increase blood glucose levels in individuals with diabetes, so diabetic therapy, such as insulin or oral medicines, may need to be adjusted. Talk to your doctor or pharmacist before taking other medications with oral corticosteroids.

Side effects

These drugs may decrease growth in children, so the lowest dose possible must be used. Long-term use may cause mood changes, osteoporosis, sleep irregularities, increased hair growth, cataracts, increased eye pressures (risk for glaucoma), roundness of the face, or thinning skin, intestinal bleeding, and increase the risk of pneumonia. Suppression of internal corticosteroid production can occur with long-term use. Therefore, if taken for several weeks, dose adjustments should be under a physician's direction. Call your doctor if you experience any of the following:

  • Itching or hives, swollen face or hands, chest tightness, breathing troubles, tingling in mouth or throat
  • Headache, eye pain, or visual troubles
  • Increased urination or thirst
  • Seizures or dizziness
  • Stomach problems, stomach pain, bloody or black stools
  • Sudden pain, swelling, or loss of movement in the lower leg
  • Sudden fluid retention or weight gain
Medically Reviewed by a Doctor on 9/11/2017

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