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Glaucoma Medications

Reviewed on 9/8/2020

What Is Glaucoma?

Glaucoma is an eye disease that is treated with surgery or medications. If untreated, glaucoma can cause permanent visual loss.
Glaucoma is an eye disease that is treated with surgery or medications. If untreated, glaucoma can cause permanent visual loss.

Glaucoma is an eye disease that, if untreated, can damage the optic nerve of the eye and result in permanent visual loss. It is usually associated with increased pressure within the eye (intraocular pressure, or IOP).

Increased intraocular pressure results from either increased production or decreased drainage of aqueous humor, a clear fluid within the front of the eye.

How Long Does It Take to Go Blind from Glaucoma?

The resulting increase in pressure within the eye may eventually damage the optic nerve. This increase in intraocular pressure is by far the most common risk factor for vision loss due to glaucoma.

What Are the Glaucoma Causes?

Many factors are associated with an increased risk of developing glaucoma, including

  • elevated intraocular pressure (IOP),
  • corneal thickness,
  • family history,
  • ethnic background, and
  • increasing age.

Glaucoma most commonly affects both eyes.

What Are the Risk Factors for Glaucoma?

  • Glaucoma affects the optic nerve and may cause vision loss. The optic nerves of both eyes transmit electrical signals from the retinas of the eyes to the brain, allowing an individual to see.
  • If the optic nerve does not function correctly, these electrical signals cannot get through, which results in vision loss, even though the rest of the eye is normal.
  • If there is failure to diagnose glaucoma or if glaucoma is not adequately treated, damage to the optic nerve may result. This damage to the optic nerve will initially be manifested by subtle loss of side vision and, if the glaucoma remains untreated, ultimately may cause loss of central vision and total blindness.
  • Vision loss from glaucoma is irreversible.

What is the Best Glaucoma Treatment?

  • Elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma, which is a progressive optic neuropathy.
  • Lowering IOP is currently the only therapeutic approach for glaucoma. Treatment is designed to reduce intraocular pressure (IOP) either by reducing production or increasing drainage of aqueous humor from the eye.
  • Depending on the type of glaucoma, medications, surgery or a combination of the two, may be used. In most patients with glaucoma, intraocular pressure can be lowered by using different medications, primarily in the form of drops placed onto the surface of the eye.

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What Are the Side Effects and Interactions of Prostaglandin Analogs?

Selective prostanoid FP-receptor (sensitive to prostaglandin F) agonists became generally available as eyedrops for the treatment of glaucoma in 1996. These include

  • latanoprost (Xalatan),
  • bimatoprost (Lumigan),
  • travoprost (Travatan and Travatan-Z),
  • unoprostone (Rescula), and
  • tafluprost (Zioptan).

The prostanoid group of eyedrops is the most commonly used first-line medication for the treatment of glaucoma. Latanoprost is currently available in a generic form.

How prostaglandins/prostanoids work

  • These drugs, administered as eyedrops, have an effect on the aqueous drainage system within the eye to increase aqueous outflow which, in turn, lowers intraocular pressure (IOP).

Who should not use these medications:

  • People allergic to prostaglandin eyedrops
  • People with inflammation (swelling) of the eye

Use 

  • These drugs are given as eyedrops to the affected eye(s).

Drug or food interactions

  • Eyedrops containing the preservative thimerosal form a crystal if administered at the same time.
  • Wait at least five minutes between applications.
  • If administered with pilocarpine eyedrops, wait at least 10 minutes — preferably, one hour — between applying the two drugs.

Side effects

  • These eyedrops should not be used while wearing contact lenses.
  • An increase in brown pigment in the iris and gradual changes in eye color may occur.
  • Eyelash growth and pigmentation may increase.
  • Skin on the eyelids and around the eyes may darken.
  • Variable loss of orbital fat has been reported.
  • Excessive tearing, eye pain, or lid crusting may occur.
  • Burning, stinging, foreign-body sensation (something in the eye), blurred vision, and itching have also been observed.

What Are the Side Effects and Interactions of Beta Adrenergic Blockers?

Beta adrenergic blockers, administered as eyedrops, became available in the late 1970s and quickly became the most commonly used drug for the treatment of glaucoma. Since the advent of the prostaglandin group of drugs, beta adrenergic locking drops have become the second most widely used therapy.

This group includes

Timolol is currently available in a generic form.

How beta-blockers work

  • These drugs lower intraocular pressure by reducing the amount of aqueous humor produced.
  • Most adrenergic beta-blockers are nonselective and block both the beta-1 and beta-2 receptors.
  • A nonselective blocker inhibits both heart muscle and opening of the airways of the lungs.
  • These are, therefore, contraindicated in patients with
  • Betaxolol (Betoptic) is a selective beta-1 receptor antagonist. Its mechanism of action is similar to timolol, but since it is a selective beta-1 blocker, it is better tolerated in patients with lung disease than is timolol.

Who should not use these medications:

Use

  • These drugs are administered as eyedrops to the affected eye(s).

Drug or food interactions

  • Ocular beta-blockers may have additive effects when used with oral beta-blockers.
  • Additive effects occur when used with other drugs that lower intraocular pressure.

Side effects

  • Beta-blockers may contain sulfites, which may cause allergic-type reactions.
  • Rarely, use may worsen or cause symptoms similarly observed with orally administered beta-blockers, such as

What Are the Side Effects and Interactions of Alpha Agonists?

Alpha agonists became available in the 1990s and are used today as third-line drugs, with prostanoids being first line and beta-blockers being second line. These include various formulations of brimonidine (Alphagan, Alphagan-P).

Alpha agonists work to both decrease production of fluid and increase drainage. Alphagan P has a purite preservative that breaks down into natural tear components and may be more effective for people who have allergic reactions to preservatives in other eyedrops. Brimonidine is currently available in a generic form.

Who should not use these medications:

  • People allergic to alpha adrenergic agonists

Use

  • These drugs are given as eyedrops to the affected eye(s).

Side effects

  • These eyedrops should not be used while wearing contact lenses.
  • Local allergic reactions are common, characterized by redness of the eyes and itching of the eyes.
  • Excessive tearing, eye pain, or lid crusting may occur.
  • Burning, stinging, foreign body sensation (something in the eye), blurred vision, and itching have also been observed.

What Are the Side Effects and Interactions of Other Adrenergic Agents?

Other adrenergic agents became available in the 1960s and are rarely used today, having been largely supplanted by alpha adrenergic agonists. These drugs lower intraocular pressure by reducing the amount of aqueous humor produced and also reduce resistance to outflow of aqueous humor.

This class of eyedrops includes

  • epinephrine (Eppy, Eppy-N) and
  • dipivefrin (AKPro, Propine).

Adrenergics may cause swelling of the macula (the center part of the retina) and eye irritation. They also may cause black deposits of the lining of the inside of the lids with extended use.

These drugs should not be used by individuals allergic to adrenergic eyedrops.

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What Are the Side Effects and Interactions of Carbonic Anhydrase Inhibitors?

Carbonic anhydrase inhibitors were initially developed as agents to treat high blood pressure (hypertension) but then were found to also decrease intraocular pressure. They reduce the action of an enzyme called carbonic anhydrase, which is necessary for the production of aqueous fluid.

The carbonic anhydrase inhibitors include the oral agents acetazolamide (Diamox) and methazolamide (Neptazane, GlaucTabs) and the eyedrops brinzolamide (Azopt) and dorzolamide (Trusopt).

The pills are rarely used today for the treatment of either glaucoma or hypertension but are effective in the treatment of altitude sickness. The drops are currently used as fourth-line therapy in glaucoma and are often used in combination with other glaucoma drops.

Who should not use these medications:

  • People allergic to carbonic anhydrase inhibitors or sulfonamides
  • People with liver or kidney disease
  • People with severe lung obstruction
  • People with inadequate adrenal function

Use

  • These drugs are given as eyedrops, pills, and for glaucoma emergencies, intravenously.

Drug or food interactions

  • When administered systemically, such as with pills or injections, carbonic anhydrase inhibitors may decrease therapeutic levels of lithium and alter the body's elimination of amphetamines, quinidine, phenobarbital, or aspirin.

Side effects

  • Individuals with liver disease may become comatose with oral administration.
  • Eyedrops may cause irritation of the eyelids.

What Are the Side Effects and Interactions of Miotics?

Miotics are eyedrops that stimulate the parasympathetic nervous system causing the pupil of the eye to become smaller. They reduce intraocular pressure by increasing the outflow of eye fluids from the eye and they are usually used to reverse angle-closure glaucoma or prevent angle-closure in eyes with narrow chamber angles.

Pilocarpine (one of the miotics) has been used for almost 150 years for the treatment of glaucoma. It is rarely utilized today to treat open-angle glaucoma.

Miotic drops include

Who should not use these medications:

  • People allergic to pilocarpine
  • People with inflammation (swelling) of the eye

Drug or food interactions

  • If administered with prostaglandin eyedrops, wait at least 10 minutes — preferably, one hour — between applying the two drugs.

Side effects

What Are the Side Effects and Interactions of Hyperosmotics?

Hyperosmotics are sugar-based liquids meant to be taken by mouth. Hyperosmotics are used in the treatment of acute-onset angle-closure glaucoma. The effects last only six to eight hours, so they are not for long-term use. Hyperosmotics include mannitol (Osmitrol), glycerin (Osmoglyn), and isosorbide (Ismotic).

Who should not use these medications:

Use

  • These drugs are given orally or can be given intravenously to rapidly correct high elevations of intraocular pressure.

Drug or food interactions

  • Hyperosmotics may decrease lithium levels.

Side effects

  • Hyperosmotics should be used with caution in people who have diseases worsened by salt retention.
  • Many patients with glaucoma require more than one type of medication for adequate control of their glaucoma.
  • Combined eyedrop medications can offer an alternative for patients who need more than one type.
  • In addition to the convenience of using one eyedrop bottle instead of two, there may also be a financial advantage, depending on the insurance plan.
  • Cosopt is a combination of a beta-blocker (timolol) and a carbonic anhydrase inhibitor (Dorzolamide).
  • Combigan combines an alpha agonist (brimonidine) with a beta-blocker (timolol).
  • Simbrinza combines an alpha agonist (brimonidine) with a carbonic anhydrase inhibitor (Brinzolamide).

There following are new drug classes used to reduce intraocular pressure in glaucoma:

  • Vesneo (latanoprostene bunod) is a glaucoma medication that combines a nitric oxide donating molecule with a prostaglandin analog.
  • Rhopressa (netarsudil ophthalmic solution) is a rho-kinase (ROCK) inhibitor that can decrease intraocular pressure by relaxing the drainage system of the aqueous.
  • Rocklatan (netarsudil and latanoprost ophthalmic solution) is a combination of a prostaglandin and ROCK inhibitor used to reduce intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

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Glaucoma Treatment

Treatment is designed to lower the IOP by reducing production or increasing outflow of aqueous humor. Depending on the type of glaucoma, medications or surgery are used. IOP usually can be lowered using different medications in the form of eyedrops and oral or IV medications.

Reviewed on 9/8/2020
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