Doctor's Notes on Granulomatosis with Polyangiitis Symptoms, Treatment, and Life Expectancy
Granulomatosis with polyangiitis (also termed Wegener’s) is a rare disease that results in inflamed blood vessels (vasculitis or polyangiitis) and nodules of inflammatory cells (granulomas) in affected tissues. The most common signs and symptoms are repeated sinusitis with pain, runny and/or bloody nose with sores and associated holes in nasal cartilage, ear infections and hearing loss. Often, people can develop shortness of breath, chest pain and coughs with some bloody sputum. Less common signs and symptoms include muscle and joint pain, joint swelling, red or purple small sores on the skin, hoarseness, fever and night sweats, weight loss. Urine may be reddish or bloody. Eye involvement can show redness, burning and eye swelling; if double vision or decreased vision occurs, it is a medical emergency.
Granulomatosis with polyangiitis is rare; its cause is unknown but thought to be an autoimmune disorder. Most signs and symptoms are due to organ damage that happens when its blood supply is compromised by the disease.
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Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.