What Are the Warning Signs of Neuropathy?

Reviewed on 6/29/2022
Man sitting on bench while doctor checks his reflexes
Warning signs of neuropathy include a “pins and needles” feeling, burning pain radiating in hands or feet, numbness and tingling, muscle weakness, pain when walking, problems walking, balance problems, knotted feeling in the soles of the feet and palms of the hands, pain from even a light touch, inability to grasp with the hands, and others.

Neuropathy refers to conditions involving damage to the nerves. Neuropathy may affect only one nerve (mononeuropathy), two or more nerves in different areas (multiple mononeuropathy or mononeuropathy multiplex), or it can affect many or most of the nerves (polyneuropathy).

Signs and symptoms of neuropathy can range from mild to disabling and depend on the type of nerve fibers affected and the type and severity of damage. Symptoms can develop over days, weeks, or years. 

17 Warning Signs of Neuropathy

Warning signs of neuropathy include: 

  • “Pins and needles” feeling 
  • Burning pain radiating in hands or feet
  • Numbness and tingling
  • Muscle weakness 
  • Pain when walking
  • Problems walking
  • Balance problems
  • Knotted feeling in the soles of the feet and palms of the hands
  • Pain from even a light touch
  • Inability to grasp with the hands
  • Painful cramps
  • Fingers twisting and locking
  • Pain when twisting the wrists
  • Hands and feet feel tired or heavy
  • Restless legs and feet
  • Pain is worse at night
  • Problems sleeping

Other symptoms of neuropathy may include:

  • Uncontrolled muscle twitching (fasciculations) 
  • Muscle shrinking
  • Diminished ability to feel vibrations and touch, especially in the hands and feet
  • Loss of reflexes 
  • Loss of position sense 
  • Diminished ability to feel pain or changes in temperature
  • Excess sweating
  • Heat intolerance
  • Inability to expand and contract the small blood vessels that regulate blood pressure
  • Gastrointestinal symptoms
  • Problems eating or swallowing (rare)

What Causes Neuropathy?

Neuropathy is caused by genetics or may be acquired, such as from the result of another disorder or condition. Sometimes, neuropathy has no known cause (idiopathic). 

Causes or triggers of symptomatic acquired neuropathy include:


What is diabetic peripheral neuropathy? See Answer

What Is the Treatment for Neuropathy?

Treatment for neuropathy depends on the type of nerve damage, symptoms, and location. 

Treating the underlying cause of the neuropathy can resolve the problem, for example:

  • Managing blood sugar in patients who have diabetes
  • Controlling inflammatory and autoimmune conditions 

Lifestyle changes that can help nerves recover and regenerate include:

  • Not smoking 
  • Eating a balanced diet
  • Maintaining a healthy weight
  • Getting regular exercise 
  • Correcting vitamin deficiencies
  • Avoiding toxic exposures

For motor symptoms of neuropathy, treatments may include: 

  • Splints for carpal tunnel syndrome
  • Mechanical aids such as hand or foot braces to reduce physical disability and pain
  • Orthopedic shoes or inserts to improve gait disturbances and prevent foot injuries
  • In severe cases, tendon transfers or bone fusions to hold the limbs in better position or to release a compressed nerve

For autonomic symptoms of neuropathy, treatments may include: 

  • Complementary techniques such as:
  • Cognitive behavioral therapy or other psychotherapeutic approaches 

For sensory symptoms of neuropathy, treatments may include:

Medications used to treat neuropathic pain are also used for other medical conditions and may include: 

Surgery to treat some types of neuropathies such as: 

  • Protruding disks (“pinched nerves”) in the back or neck 
  • Trigeminal neuralgia on the face 
  • Injuries to a single nerve (mononeuropathy) caused by compression, entrapment, or rarely, tumors or infections 

Transcutaneous electrical nerve stimulation (TENS) is a treatment that involves attaching electrodes to the skin at the site of pain or near associated nerves and then administering a gentle electrical current. TENS may improve neuropathic symptoms associated with diabetes.

Health Solutions From Our Sponsors

Reviewed on 6/29/2022

Image Source: iStock Images