- Genetics: canker sores often run in families
- Mouth injuries, including biting the inside of the lip or brushing the teeth too vigorously
- Sodium lauryl sulfate (SLS), a common ingredient in toothpastes and mouthwashes
- Immune system problems
- Nutritional deficiencies including low vitamin B12, iron, folate, or zinc
What Are Canker Sores?
Canker sores (also called aphthous ulcers or aphthous stomatitis) are common small and painful ulcers that form inside the mouth, usually occurring on the tongue, inner lining of the cheeks or lips, and the throat.
What Are Symptoms of Canker Sores?
Canker sores are oral ulcers with a characteristic appearance:
- Round or oval shape
- Red rim
- Yellow colored fluid in center
- Size varies from smaller than 1 mm to larger than 1 cm
- Lesions usually start as a pinpoint-sized bump and develop into an ulcer over 1 to 2 days, reaching their largest size in 3 to 4 days before beginning to heal
How Can I Get Fast Relief for Canker Sores?
A canker sore lesion usually starts as a pinpoint-sized bump and develops into an ulcer over 1 to 2 days, reaching its largest size in 3 to 4 days before starting to heal. Most of the time, canker sores go away on their own within 2 weeks.
Treatment for canker sores is aimed at relieving pain, speeding healing, and decreasing their recurrence.
Topical anesthetics can provide fast relief for canker sore pain.
Treatment for canker sores includes:
- Proper oral hygiene
- Avoid behaviors that can injure the mouth
- Don’t bite the inside of the lips or cheeks
- Avoid foods that trigger sores
- Reduce sharp or rough edges on braces and dental restorations
- Pain medicines
- Topical anesthetics
- Topical corticosteroids for mild to moderate canker sores
- Topical antibiotics (mouth rinses, gels, or pastes) to control secondary infection
- Vitamins and dietary supplements if there are diagnosed nutritional deficiencies (e.g., vitamin B12, folate, iron, zinc)
For severe cases of canker sores that do not respond to traditional therapies, treatments may include:
- Colchicine, taken with or without dapsone
- Thalidomide: for severe canker sores and mucocutaneous lesions of Behçet syndrome and for oral ulcers in HIV patients
- Apremilast: helps inhibit production of proinflammatory cytokines
- Montelukast: may relieve pain and improve healing of oral ulcers
- Cyclosporine: used to treat mucocutaneous ulcers in patients with Behçet syndrome, and may be effective in patients with complex sores
- Biologic agents
- Pentoxifylline: benefits may be limited
- Laser therapy: may help relieve canker sores but more study is needed
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