What Does NMN Do for the Body?

Reviewed on 8/4/2022

An elderly man talking to his doctor
NMN (nicotinamide mononucleotide) has many health and anti-aging benefits, including it extends lifespan, prevents age-associated weight gain, improves insulin sensitivity, promotes vascular health and blood flow, enhances energy metabolism and physical activity, improves muscle endurance and strength, protects against heart disease, and others.

NMN (nicotinamide mononucleotide) is a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all living cells. Increased intracellular levels of NAD+ trigger shifts in all living species that enhance survival, including boosting energy production and increasing the rate of cellular repair.

Where NMN and NAD+ can come into play is in the process of aging. By middle age, the body’s NAD+ levels drop to half that of youth. Signs of aging can be described as a breakdown triggered by decreased systemic production of NAD+ and the resulting functional declines in the body’s organs and tissues. 

NMN supplementation may be an effective anti-aging intervention. One of the ways NAD+ levels can be increased is supplementing with NAD precursors, such as NMN. When taken orally, NMN is absorbed and converted to NAD+ in the body. 

A number of studies have shown that increasing NAD+ levels:

  • Increases insulin sensitivity
  • Reverses mitochondrial dysfunction
  • Extends lifespan

Several studies have shown NMN supplementation: 

  • Increases NAD+ biosynthesis
  • Prevents age-associated weight gain
  • Improves insulin sensitivity
  • Promotes vascular health and blood flow
  • Enhances energy metabolism and physical activity
  • Improves muscle endurance and strength
  • Protects against heart disease
  • Improves neuronal function in the brain 
  • Improves eye function
  • Prevents age-related changes in gene expression

What Is the Dose of NMN?

  • The recommended dose of NMN (nicotinamide mononucleotide) for adults between 30 and 60 years old is 500 mg per day. 
  • Adults over age 65 can may take up to 750 mg per day.

What Are Side Effects of NMN?

  • There are currently no side effects of NMN (nicotinamide mononucleotide) documented in humans. 
  • One small study showed that doses of up to 500 mg of NMN taken orally are safe in humans, though more study is needed. 
  • Several clinical trials are underway to test the effect of NMN supplementation on the body and to determine any possible side effects.


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Reviewed on 8/4/2022

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