NMN (nicotinamide mononucleotide) is a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all living cells. Increased intracellular levels of NAD+ trigger shifts in all living species that enhance survival, including boosting energy production and increasing the rate of cellular repair.
Where NMN and NAD+ can come into play is in the process of aging. By middle age, the body’s NAD+ levels drop to half that of youth. Signs of aging can be described as a breakdown triggered by decreased systemic production of NAD+ and the resulting functional declines in the body’s organs and tissues.
NMN supplementation may be an effective anti-aging intervention. One of the ways NAD+ levels can be increased is supplementing with NAD precursors, such as NMN. When taken orally, NMN is absorbed and converted to NAD+ in the body.
A number of studies have shown that increasing NAD+ levels:
- Increases insulin sensitivity
- Reverses mitochondrial dysfunction
- Extends lifespan
Several studies have shown NMN supplementation:
- Increases NAD+ biosynthesis
- Prevents age-associated weight gain
- Improves insulin sensitivity
- Promotes vascular health and blood flow
- Enhances energy metabolism and physical activity
- Improves muscle endurance and strength
- Protects against heart disease
- Improves neuronal function in the brain
- Improves eye function
- Prevents age-related changes in gene expression
What Is the Dose of NMN?
- The recommended dose of NMN (nicotinamide mononucleotide) for adults between 30 and 60 years old is 500 mg per day.
- Adults over age 65 can may take up to 750 mg per day.
What Are Side Effects of NMN?
- There are currently no side effects of NMN (nicotinamide mononucleotide) documented in humans.
- One small study showed that doses of up to 500 mg of NMN taken orally are safe in humans, though more study is needed.
- Several clinical trials are underway to test the effect of NMN supplementation on the body and to determine any possible side effects.
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